Author, as appears in the article.: Paton B; Suarez M; Herrero P; Canela N
Department: Bioquímica i Biotecnologia
URV's Author/s: HERRERO GIL, POL / Paton Jiménez, Beatrix / Suárez Recio, Manuel
Keywords: Sialic-acid Protein glycosylation N-linked oligosaccharides N-glycan Mass spectrometry Liquid-chromatography Lc-ms/ms analysis Immunoglobulin-g Igg fc Hydrophilic-interaction chromatography High-throughput Glycosylation Glycan analysis Desorption/ionization mass-spectrometry Ageing Age-related disease
Abstract: Ageing is a complex process which implies the accumulation of molecular, cellular and organ damage, leading to an increased vulnerability to disease. In Western societies, the increase in the elderly population, which is accompanied by ageing-associated pathologies such as cardiovascular and mental diseases, is becoming an increasing economic and social burden for governments. In order to prevent, treat and determine which subjects are more likely to develop these age-related diseases, predictive biomarkers are required. In this sense, some studies suggest that glycans have a potential role as disease biomarkers, as they modify the functions of proteins and take part in intra-and intercellular biological processes. As the glycome reflects the real-time status of these interactions, its characterisation can provide potential diagnostic and prognostic biomarkers for multifactorial diseases. This review gathers the alterations in protein glycosylation profiles that are associated with ageing and age-related diseases, such as cancer, type 2 diabetes mellitus, metabolic syndrome and several chronic inflammatory diseases. Furthermore, the review includes the available techniques for the determination and characterisation of glycans, such as liquid chromatography, electrophoresis, nuclear magnetic resonance and mass spectrometry.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: beatrix.paton@estudiants.urv.cat manuel.suarez@urv.cat
Author identifier: 0000-0003-0122-8253
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1422-0067/22/11/5788
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Molecular Sciences. 22 (11):
APA: Paton B; Suarez M; Herrero P; Canela N (2021). Glycosylation biomarkers associated with age-related diseases and current methods for glycan analysis. International Journal Of Molecular Sciences, 22(11), -. DOI: 10.3390/ijms22115788
Article's DOI: 10.3390/ijms22115788
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications