Author, as appears in the article.: Carrasquer, Anna; Peiro, Oscar M.; Sanchez-Gimenez, Raul; Lal-Trehan, Nisha; del-Moral-Ronda, Victor; Bonet, Gil; Gutierrez, Cristina; Fort-Gallifa, Isabel; Martin-Grau, Carla; Benavent, Clara; Vidal, Francesc; Bardaji, Alfredo;
Department: Medicina i Cirurgia
e-ISSN: 1476-1645
URV's Author/s: Bardají Ruiz, Alfredo / Bonet Pineda, Gil / Carrasquer Cucarella, Ana Maria / Peiró Ibáñez, Óscar Manuel / Sánchez Giménez, Raúl / Vidal Marsal, Francisco
Keywords: Virus load Troponin i Severe acute respiratory syndrome coronavirus 2 Risk factor Retrospective study Real time polymerase chain reaction Prediction Observational study Nonhuman Male Major clinical study Intensive care unit Human Hospital mortality Hospital admission Female Demography Coronavirus disease 2019 Comorbidity Cohort analysis Artificial ventilation Article Aged Adult
Abstract: Controversy exists in the literature regarding the possible prognostic implications of the nasopharyngeal SARS-CoV-2 viral load. We carried out a retrospective observational study of 169 patients, 96 (58.9%) of whom had a high viral load and the remaining had a low viral load. Compared with patients with a low viral load, patients with a high viral load did not exhibit differences regarding preexisting cardiovascular risk factors or comorbidities. There were no differences in symptoms, vital signs, or laboratory tests in either group, except for the maximum cardiac troponin I (cTnI), which was higher in the group with a higher viral load (24 [interquartile range 9.5-58.5] versus 8.5 [interquartile range 3-22.5] ng/L, P = 0.007). There were no differences in the need for hospital admission, admission to the intensive care unit, or the need for mechanical ventilation in clinical management. In-hospital mortality was greater in patients who had a higher viral load than in those with low viral load (24% versus 10.4%, P = 0.029). High viral loads were associated with in-hospital mortality in the binary logistic regression analysis (odds ratio: 2.701, 95% Charlson Index (CI): 1.084-6.725, P = 0.033). However, in an analysis adjusted for age, gender, CI, and cTnI, viral load was no longer a predictor of mortality. In conclusion, an elevated nasopharyngeal viral load was not a determinant of in-hospital mortality in patients with COVID-19, as much as age, comorbidity, and myocardial damage determined by elevated cTnI are.
Thematic Areas: Zootecnia / recursos pesqueiros Virology Tropical medicine Serviço social Saúde coletiva Química Public, environmental & occupational health Psicología Parasitology Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gil.bonet@urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat raul.sanchez@estudiants.urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat alfredo.bardaji@urv.cat francesc.vidal@urv.cat
Author identifier: 0000-0003-1900-6974 0000-0002-6692-6186
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.ajtmh.org/view/journals/tpmd/104/2/article-p540.xml
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: American Journal Of Tropical Medicine And Hygiene. 104 (2): 540-545
APA: Carrasquer, Anna; Peiro, Oscar M.; Sanchez-Gimenez, Raul; Lal-Trehan, Nisha; del-Moral-Ronda, Victor; Bonet, Gil; Gutierrez, Cristina; Fort-Gallifa, I (2021). Lack of Association of Initial Viral Load in SARS-CoV-2 Patients with In-Hospital Mortality. American Journal Of Tropical Medicine And Hygiene, 104(2), 540-545. DOI: 10.4269/ajtmh.20-1427
Article's DOI: 10.4269/ajtmh.20-1427
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications