Author, as appears in the article.: Hernáez Á; Lassale C; Castro-Barquero S; Babio N; Ros E; Castañer O; Tresserra-Rimbau A; Pintó X; Martínez-González MÁ; Corella D; Salas-Salvadó J; Alonso-Gómez ÁM; Lapetra J; Fiol M; Gómez-Gracia E; Serra-Majem L; Sacanella E; García-Arellano A; Sorlí JV; Díaz-López A; Cofán M; Estruch R
Department: Bioquímica i Biotecnologia
URV's Author/s: Alkhoury, Nadine / Babio Sánchez, Nancy Elvira / Díaz López, Andres / Salas Salvadó, Jorge
Keywords: White blood cell count Randomized controlled trial Prevention Physical-activity questionnaire Mediterranean diet Leukopenia Leukocytosis randomized controlled trial prevention nutrition mortality mediterranean diet leukopenia leukocytosis leukocyte count inflammation high-cardiovascular risk health disease adults adherence
Abstract: We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36-0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10-0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085-0.99]) and attenuated the association between leukopenia and all-cause mortality (Pinteraction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.
Thematic Areas: Plant science Microbiology Health professions (miscellaneous) Health (social science) Food science & technology Food science
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andres.diaz@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-07-27
Journal volume: 10
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Foods. 10 (6):
APA: Hernáez Á; Lassale C; Castro-Barquero S; Babio N; Ros E; Castañer O; Tresserra-Rimbau A; Pintó X; Martínez-González MÁ; Corella D; Salas-Salvadó J; Al (2021). Mediterranean diet and white blood cell count-a randomized controlled trial. Foods, 10(6), -. DOI: 10.3390/foods10061268
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV