Author, as appears in the article.: Lassale, Camille; Hernaez, Alvaro; Toledo, Estefania; Castaner, Olga; Sorli, Jose V.; Salas-Salvado, Jordi; Estruch, Ramon; Ros, Emilio; Alonso-Gomez, Angel M.; Lapetra, Jose; Cueto, Raquel; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Gea, Alfredo; Corella, Dolores; Babio, Nancy; Fito, Montserrat; Schroder, Helmut;
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Keywords: Weight-loss Validation Spain Sex Risk reduction Randomized controlled trial Prospective study Prospective studies Proportional hazards models Proportional hazards model Primary prevention Population Physical-activity questionnaire Physical activity Nut Neoplasms Neoplasm Multicenter study Mortality risk Mortality Mediterranean diet Male Major clinical study Low density lipoprotein cholesterol Humans Human High density lipoprotein cholesterol Health Food frequency questionnaire Follow up Female Extra virgin olive oil Exercise Epidemiology Energy metabolism Energy intake Energy expenditure Energy balance Diet surveys Diet Controlled study Cohort analysis Clinical study Cholesterol blood level Cause of death Cardiovascular-disease Cardiovascular risk Cardiovascular mortality Cardiovascular diseases Cardiovascular disease Cancer mortality Caloric restriction Caloric intake Body weight change Body weight Body height Association Article All-cause mortality All cause mortality Aging Aged Age Adult
Abstract: Clinical data on the direct health effects of energy deficit or surplus beyond its impact on body weight are scarce. We aimed to assess the association with all-cause, cardiovascular and cancer mortality of (1) sustained energy deficit or surplus, calculated according to each individual's en-ergy intake (EI) and theoretical energy expenditure (TEE), and (2) mid-term change in total EI in a prospective study. In 7119 participants in the PREDIMED Study (PREvencion con DIeta MEDi-terranea) with a mean age of 67 years, energy intake was derived from a 137-item food frequency questionnaire. TEE was calculated as a function of age, sex, height, body weight and physical ac-tivity. The main exposure was the proportion of energy requirement covered by energy intake, cumulative throughout the follow-up. The secondary exposure was the change in energy intake from baseline. Cox proportional hazard models were used to estimate hazard ratios and 95% con-fidence intervals for all-cause, cardiovascular and cancer mortality. Over a median follow-up of 4.8 years, there were 239 deaths (excluding the first 2 years). An energy intake exceeding energy needs was associated with an increase in mortality risk (continuous HR10% over energy needs = 1.10; 95% CI 1.02, 1.18), driven by cardiovascular death (HR = 1.26; 95% CI 1.11, 1.43). However, consum-ing energy below estimated needs was not associated with a lower risk. Increments over time in energy intake were associated with greater all-cause mortality (HR10% increase = 1.09; 95% CI 1.02, 1.17). However, there was no evidence that a substantial negative change in energy intake would reduce mortality risk. To conclude, in an older Mediterranean cohort, energy surplus or increase over a 5-year period was associated with greater risk of mortality, particularly cardiovascular mortality. Energy deficit, or reduction in energy intake over time were not associated with mortal-ity risk.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/13/5/1545
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 13 (5):
APA: Lassale, Camille; Hernaez, Alvaro; Toledo, Estefania; Castaner, Olga; Sorli, Jose V.; Salas-Salvado, Jordi; Estruch, Ramon; Ros, Emilio; Alonso-Gomez, (2021). Energy Balance and Risk of Mortality in Spanish Older Adults. Nutrients, 13(5), -. DOI: 10.3390/nu13051545
Article's DOI: 10.3390/nu13051545
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV