Author, as appears in the article.: Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilman; Weiderpass, Elisabete; Tumino, Rosario; Redondo-Sanchez, Daniel; de Magistris, Maria Santucci; Palli, Domenico; Ardanaz, Eva; Laouali, Nasser; Sonestedt, Emily; Drake, Isabel; Rizzolo, Lucia; Santiuste, Carmen; Sacerdote, Carlotta; Quiros, Ramon; Amiano, Pilar; Agudo, Antonio; Jakszyn, Paula;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Aranda Pons, Núria / Arija Val, Maria Victoria / Iglesias Vazquez, Lucia
Keywords: Serum ferritin Risk Physical-activity Overload Iron status Iron overload Hfe c282y Hemochromatosis Excess iron Epic Dietary Danish men Cancer Body iron Alcohol-consumption
Abstract: Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 mu g/L and 35.2% in males, respectively, and 77 mu g/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (similar to 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
Thematic Areas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nuria.aranda@urv.cat lucia.iglesias@urv.cat victoria.arija@urv.cat
Author identifier: 0000-0001-9708-747X 0000-0001-7131-4144 0000-0002-1758-0975
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://link.springer.com/article/10.1007%2Fs00394-021-02625-w
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Journal Of Nutrition. 61 (1): 101-114
APA: Iglesias-Vazquez, Lucia; Arija, Victoria; Aranda, Nuria; Aglago, Elom K.; Cross, Amanda J.; Schulze, Matthias B.; Quintana Pacheco, Daniel; Kuhn, Tilm (2022). Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study. European Journal Of Nutrition, 61(1), 101-114. DOI: 10.1007/s00394-021-02625-w
Article's DOI: 10.1007/s00394-021-02625-w
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV