Author, as appears in the article.: Pinos, Helena; Carrillo, Beatriz; Merchan, Ana; Biosca-Brull, Judit; Perez-Fernandez, Cristian; Colomina, Maria Teresa; Sanchez-Santed, Fernando; Martin-Sanchez, Fernando; Collado, Paloma; Arias, Jorge L.; Conejo, Nelida M.;

Department: Psicologia

URV's Author/s: Biosca Brull, Judit / Colomina Fosch, Maria Teresa

Keywords: Unclassified drug Systematic review Sex-differences Review Rapid weight-gain Pyrethroids Pyrethroid pesticide Pyrethroid Pyrethrins Progeny Pregnancy Pollution exposure Pesticides Pesticide Persistent organic pollutants Perinatal drug exposure Oxidative stress Organophosphates Organophosphate Organochlorine pesticide Organochlorine derivative Organochlorine Obesity Nonhuman Neonicotinoids Neonicotinoid pesticide Neonicotinoid Metabolic syndrome x Lipid storage Lipid metabolism Lactation Humans Human High-fat diet Hexachlorobenzene Halophenol Glucose blood level Glucose Female Fat mass Environmental factor Environmental exposure Environmental contaminants Drug effect Disrupting chemicals Disease association Dichlorophenol Developmental exposure Depression Clinical outcome Chlorpyrifos Chlordecone Child health Child Cardiometabolic risk Carbamic acid Carbamates Carbamate (ester) Body weight Body mass Body fat Beta hexachlorocyclohexane Adverse event Adult Adipose-tissue Abdominal circumference

Abstract: In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.

Thematic Areas: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental studies Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: judit.biosca@urv.cat mariateresa.colomina@urv.cat judit.biosca@urv.cat

Author identifier: 0000-0002-5619-4874

Record's date: 2023-08-05

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1660-4601/18/13/7170

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Environmental Research And Public Health. 18 (13):

APA: Pinos, Helena; Carrillo, Beatriz; Merchan, Ana; Biosca-Brull, Judit; Perez-Fernandez, Cristian; Colomina, Maria Teresa; Sanchez-Santed, Fernando; Mart (2021). Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review. International Journal Of Environmental Research And Public Health, 18(13), -. DOI: 10.3390/ijerph18137170

Article's DOI: 10.3390/ijerph18137170

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications