Author, as appears in the article.: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Toft Hansen, Thea; Harrold, Joanne A; Sjodin, Anders; Halford, Jason C G; Bullo, Monica
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica
Keywords: Weight reduction programs Weight maintenance Weight loss Satin Phospholipids Overweight Obese adults Middle aged Metabolomics Metaanalysis Management Male Lysophosphatidylcholines Loss diets Lipids Intervention Insulin-resistance Individuals Humans Female Citric acid Caloric restriction Bone Body weight Body composition Blood Adult Adiposity
Abstract: Scope To examine the relationship between changes in circulating metabolites during diet-induced weight loss and changes of adiposity. This study also investigates changes in these metabolites in relation to body weight and adiposity regain during a weight loss maintenance period. Methods and Results This cohort study is nested within the Satiety Innovation (SATIN) study. Participants (n = 162) achieving >= 8% weight loss during an initial 8-week low-calorie formula diet (LCD) are included in a 12-week weight loss maintenance period. A targeted metabolite profiling (123 metabolites) approach is applied using three different platforms (proton nuclear magnetic resonance, liquid chromatography mass spectrometry, gas chromatography mass spectrometry). Changes in several lipid species and citric acid are significantly associated with greater reduction of body weight, total fat, and abdominal adiposity distribution during the LCD. Decreases in the concentrations of lysophosphatidylcholines (LPCs) 14:0, LPC 20:3, phosphatidylcholine (PC) 32:2, PC 38:3, sphingomyelin (SM) 32:2, and increases in citric acid concentrations during the LCD are associated with adiposity regain and loss, respectively, during the weight loss maintenance period. Conclusions The results show that weight loss is associated with changes in lipid species and citric acid. These changes are related to subsequent weight and adiposity regain identifying the adipose lipid metabolism as an important factor for the maintenance of lost weight and adiposity.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: monica.bullo@urv.cat
Author identifier: 0000-0002-0218-7046
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202001154
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 65 (17): 2001154-
APA: Papandreou, Christopher; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Toft Hansen, Thea; Harrold, Joanne A; Sjodin, Anders; Halford, Jason C G; Bullo (2021). Changes in Circulating Metabolites During Weight Loss are Associated with Adiposity Improvement, and Body Weight and Adiposity Regain During Weight Loss Maintenance: The SATIN Study. Molecular Nutrition & Food Research, 65(17), 2001154-. DOI: 10.1002/mnfr.202001154
Article's DOI: 10.1002/mnfr.202001154
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV