Articles producció científica> Bioquímica i Biotecnologia

Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies

  • Identification data

    Identifier: imarina:9225164
    Authors:
    Ruskovska, TatjanaBudic-Leto, IrenaCorral-Jara, Karla FabiolaAjdzanovic, VladimirArola-Arnal, AnnaBravo, Francisca IsabelDeligiannidou, Georgia-EiriniHavlik, JaroslavJaneva, MilkicaKistanova, ElenaKontogiorgis, ChristosKrga, IrenaMassaro, MarikaMiler, MarkoMilosevic, VericaMorand, ChristineScoditti, EgeriaSuarez, ManuelVauzour, DavidMilenkovic, Dragan
    Abstract:
    Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
  • Others:

    Author, as appears in the article.: Ruskovska, Tatjana; Budic-Leto, Irena; Corral-Jara, Karla Fabiola; Ajdzanovic, Vladimir; Arola-Arnal, Anna; Bravo, Francisca Isabel; Deligiannidou, Georgia-Eirini; Havlik, Jaroslav; Janeva, Milkica; Kistanova, Elena; Kontogiorgis, Christos; Krga, Irena; Massaro, Marika; Miler, Marko; Milosevic, Verica; Morand, Christine; Scoditti, Egeria; Suarez, Manuel; Vauzour, David; Milenkovic, Dragan;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / Suárez Recio, Manuel
    Keywords: Transcription factor rela Tnf signaling Systematic literature search Stat1 protein Sirtuin 1 Signal transduction Rna, messenger Real-time polymerase chain reaction Real time polymerase chain reaction Protein c jun Protective agents Protective agent Ppar signaling Polyphenols Polyphenol Pi3k/akt signaling Peroxisome proliferator activated receptor Oxidative stress Olive oil polyphenols Nutritional physiological phenomena Nutrition Nutrigenomics Nonhuman Middle aged Micrornas Microrna Metabolic syndrome x Metabolic syndrome Messenger rna Mapk signaling Male Integrative bioinformatics Insulin-resistance In-vivo Immunoglobulin enhancer binding protein Humans Human Genetics Genes Gene expression Female Expression Endothelial-cells Dietary-intake Computational biology Cardiometabolic risk factors Cardiometabolic risk Cardiometabolic health Blood mononuclear-cells Blood cell Blood Biology Bioinformatics Article Adult Adipose-tissue
    Abstract: Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: franciscaisabel.bravo@urv.cat manuel.suarez@urv.cat anna.arola@urv.cat
    Author identifier: 0000-0002-6468-3088 0000-0003-0122-8253 0000-0001-6529-1345
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/7/2326
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (7):
    APA: Ruskovska, Tatjana; Budic-Leto, Irena; Corral-Jara, Karla Fabiola; Ajdzanovic, Vladimir; Arola-Arnal, Anna; Bravo, Francisca Isabel; Deligiannidou, Ge (2021). Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans-Evidence from Targeted Nutrigenomic Studies. Nutrients, 13(7), -. DOI: 10.3390/nu13072326
    Article's DOI: 10.3390/nu13072326
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Transcription factor rela
    Tnf signaling
    Systematic literature search
    Stat1 protein
    Sirtuin 1
    Signal transduction
    Rna, messenger
    Real-time polymerase chain reaction
    Real time polymerase chain reaction
    Protein c jun
    Protective agents
    Protective agent
    Ppar signaling
    Polyphenols
    Polyphenol
    Pi3k/akt signaling
    Peroxisome proliferator activated receptor
    Oxidative stress
    Olive oil polyphenols
    Nutritional physiological phenomena
    Nutrition
    Nutrigenomics
    Nonhuman
    Middle aged
    Micrornas
    Microrna
    Metabolic syndrome x
    Metabolic syndrome
    Messenger rna
    Mapk signaling
    Male
    Integrative bioinformatics
    Insulin-resistance
    In-vivo
    Immunoglobulin enhancer binding protein
    Humans
    Human
    Genetics
    Genes
    Gene expression
    Female
    Expression
    Endothelial-cells
    Dietary-intake
    Computational biology
    Cardiometabolic risk factors
    Cardiometabolic risk
    Cardiometabolic health
    Blood mononuclear-cells
    Blood cell
    Blood
    Biology
    Bioinformatics
    Article
    Adult
    Adipose-tissue
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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