Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

  • Identification data

    Identifier: imarina:9225433
    Handle: http://hdl.handle.net/20.500.11797/imarina9225433
  • Authors:

    Youssef L
    Simões RV
    Miranda J
    García-Martín ML
    Paules C
    Crovetto F
    Amigó N
    Cañellas N
    Gratacos E
    Crispi F
  • Others:

    Author, as appears in the article.: Youssef L; Simões RV; Miranda J; García-Martín ML; Paules C; Crovetto F; Amigó N; Cañellas N; Gratacos E; Crispi F
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Cañellas Alberich, Nicolau
    Keywords: Nmr-spectroscopy pulsatility index plasma metabolism lipoprotein identification diagnosis consequences biomarkers 1st-trimester prediction
    Abstract: Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies with normotensive FGR, PE without FGR, PE + FGR and uncomplicated pregnancies as controls. Nuclear magnetic resonance metabolomics were applied on plasma samples collected at delivery. Advanced lipoprotein, glycoprotein and choline profiling was performed using the Liposcale test. The software package Dolphin was used to quantify 24 low-molecular-weight metabolites. Statistical analysis comprised the comparison between each group of complicated pregnancies versus controls, considering 5% false discovery rate correction. Lipid profiles were altered in accordance with the clinical presentation of these disorders. Specifically, PE mothers and FGR fetuses (with or without FGR or PE, respectively) exhibited a pro-atherogenic and pro-inflammatory profile, with higher concentrations of triglycerides, remnant cholesterol (VLDL, IDL) and Glc/GalNAc-linked and lipid-associated glycoproteins compared to controls. Low-molecular-weight metabolites were extensively disturbed in preeclamptic mothers, with or without FGR. Growth restricted fetuses in the presence of PE showed changes in low-molecular-weight metabolites similar to their mothers (increased creatine and creatinine), while normotensive FGR fetuses presented scarce differences, consistent with undernutrition (lower isoleucine). Further research is warranted to clarify maternal and fetal adaptations to PE and FGR.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nicolau.canyellas@urv.cat
    Author identifier: 0000-0003-4856-8132
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-021-93936-9
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Scientific Reports. 11 (1):
    APA: Youssef L; Simões RV; Miranda J; García-Martín ML; Paules C; Crovetto F; Amigó N; Cañellas N; Gratacos E; Crispi F (2021). Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction. Scientific Reports, 11(1), -. DOI: 10.1038/s41598-021-93936-9
    Article's DOI: 10.1038/s41598-021-93936-9
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Nmr-spectroscopy
    pulsatility index
    plasma
    metabolism
    lipoprotein
    identification
    diagnosis
    consequences
    biomarkers
    1st-trimester prediction
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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