Author, as appears in the article.: Galie, Serena; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Atzeni, Alessandro; Muralidharan, Jananee; Papandreou, Christopher; Arcelin, Pierre; Palau-Galindo, Antoni; Garcia, David; Basora, Josep; Arias-Vasquez, Alejandro; Bullo, Monica
Department: Dret Públic
URV's Author/s: Atzeni, Alessandro / Bulló Bonet, Mònica / Galiè, Serena / García Gavilán, Jesús Francisco / Muralidharan, Jananee / Palau Galindo, Antonio
Keywords: Walnuts Pistachio consumption Nuts Modulation Middle aged Metabolome Mediterranean diet Insulin resistance Insulin Humans Gut microbiota Gastrointestinal microbiome Feces Fecal metabolites Diet, mediterranean Cholesterol Cardiometabolic risk factors
Abstract: Scope To examine whether a Mediterranean Diet (MedDiet) compared to the consumption of nuts in the context of a habitual non-MedDiet exerts a greater beneficial effect on gut microbiota and fecal metabolites; thus, contributing to explain major benefits on cardiometabolic risk factors. Methods and Results Fifty adults with Metabolic Syndrome are randomized to a controlled, crossover 2-months dietary-intervention trial with a 1-month wash-out period, following a MedDiet or consuming nuts (50 g day(-1)). Microbiota composition is assessed by 16S rRNA gene sequencing and metabolites are measured using Nuclear Magnetic Resonance (NMR) and liquid chromatography coupled to triple quadrupole mass spectrometry (LC-qTOF) platforms in a targeted metabolomics approach. Decreased glucose, insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) is observed after the MedDiet compared to the nuts intervention. Relative abundances of Lachnospiraceae NK4A136 and an uncultured genera of Ruminococcaceae are significantly increased after the MedDiet compared to nuts supplementation. Changes in Lachnospiraceae NK4A136 are inversely associated with insulin levels and HOMA-IR, while positively and negatively with changes in cholate and cadaverine, respectively. Conclusions Following a MedDiet, rather than nuts, induces a significant increase in Lachnospiraceae NK4A136 and improves the metabolic risk. This genera seems to affect the bile acid metabolism and cadaverine which may account for the improvement in insulin levels.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: antonio.palau@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat monica.bullo@urv.cat
Author identifier: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0002-0218-7046
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000982
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 65 (19): 2000982-
APA: Galie, Serena; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Atzeni, Alessandro; Muralidharan, Jananee; Papandreou, Christopher; Arcelin, Pierre; Pala (2021). Effects of the Mediterranean Diet or Nut Consumption on Gut Microbiota Composition and Fecal Metabolites and their Relationship with Cardiometabolic Risk Factors. Molecular Nutrition & Food Research, 65(19), 2000982-. DOI: 10.1002/mnfr.202000982
Article's DOI: 10.1002/mnfr.202000982
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications