Author, as appears in the article.: Galie, Serena; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Atzeni, Alessandro; Muralidharan, Jananee; Papandreou, Christopher; Arcelin, Pierre; Palau-Galindo, Antoni; Garcia, David; Basora, Josep; Arias-Vasquez, Alejandro; Bullo, Monica;

Department: Dret Públic

URV's Author/s: Atzeni, Alessandro / Bulló Bonet, Mònica / Muralidharan, Jananee

Keywords: Walnuts Pistachio consumption Nuts Modulation Mediterranean diet Insulin resistance Gut microbiota Fecal metabolites Cholesterol

Abstract: Scope To examine whether a Mediterranean Diet (MedDiet) compared to the consumption of nuts in the context of a habitual non-MedDiet exerts a greater beneficial effect on gut microbiota and fecal metabolites; thus, contributing to explain major benefits on cardiometabolic risk factors. Methods and Results Fifty adults with Metabolic Syndrome are randomized to a controlled, crossover 2-months dietary-intervention trial with a 1-month wash-out period, following a MedDiet or consuming nuts (50 g day(-1)). Microbiota composition is assessed by 16S rRNA gene sequencing and metabolites are measured using Nuclear Magnetic Resonance (NMR) and liquid chromatography coupled to triple quadrupole mass spectrometry (LC-qTOF) platforms in a targeted metabolomics approach. Decreased glucose, insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) is observed after the MedDiet compared to the nuts intervention. Relative abundances of Lachnospiraceae NK4A136 and an uncultured genera of Ruminococcaceae are significantly increased after the MedDiet compared to nuts supplementation. Changes in Lachnospiraceae NK4A136 are inversely associated with insulin levels and HOMA-IR, while positively and negatively with changes in cholate and cadaverine, respectively. Conclusions Following a MedDiet, rather than nuts, induces a significant increase in Lachnospiraceae NK4A136 and improves the metabolic risk. This genera seems to affect the bile acid metabolism and cadaverine which may account for the improvement in insulin levels.

Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: alessandro.atzeni@urv.cat monica.bullo@urv.cat alessandro.atzeni@urv.cat

Author identifier: 0000-0002-1804-8606 0000-0002-0218-7046 0000-0002-1804-8606

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202000982

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Molecular Nutrition & Food Research. 65 (19):

APA: Galie, Serena; Garcia-Gavilan, Jesus; Camacho-Barcia, Lucia; Atzeni, Alessandro; Muralidharan, Jananee; Papandreou, Christopher; Arcelin, Pierre; Pala (2021). Effects of the Mediterranean Diet or Nut Consumption on Gut Microbiota Composition and Fecal Metabolites and their Relationship with Cardiometabolic Risk Factors. Molecular Nutrition & Food Research, 65(19), -. DOI: 10.1002/mnfr.202000982

Article's DOI: 10.1002/mnfr.202000982

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications