Author, as appears in the article.: Dominguez-Lopez, Ines; Parilli-Moser, Isabella; Arancibia-Riveros, Camila; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel Angel; Ortega-Azorin, Carolina; Salas-Salvado, Jordi; Castaner, Olga; Lapetra, Jose; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Gomez-Gracia, Enrique; Ros, Emilio; Lamuela-Raventos, Rosa M; Estruch, Ramon
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Wine; Waist to height ratio; Waist circumference; Very elderly; Vegetable consumption; Urine sampling; Urine level; Urine; Tartrates; Tartaric acid; Tandem mass spectrometry; Sirtuin 1; Resveratrol; Red wine; Randomized controlled trials as topic; Randomized controlled trial (topic); Randomized controlled trial; Questionnaire; Predimed; Polyphenols; Physical activity; People by smoking status; Oral antidiabetic agent; Multicenter study; Middle aged; Menopause; Mediterranean diet; Male; Major clinical study; Low density lipoprotein cholesterol level; Low density lipoprotein cholesterol; Liquid chromatography-mass spectrometry; Liquid chromatography; Lipid profile; Insulin treatment; Insulin; Hydroxymethylglutaryl coenzyme a reductase inhibitor; Humans; Human; Heart disease risk factors; Health; Glucose blood level; Glucose; Fruit consumption; Female; Electrospray mass spectrometry; Educational status; Drinking behavior; Diuretic agent; Dipeptidyl carboxypeptidase inhibitor; Cross-sectional study; Cross-sectional studies; Coronary-heart-disease; Controlled study; Consumption; Clinical trial; Cholesterol, ldl; Cholesterol blood level; Cholesterol; Cardiovascular risk-factors; Cardiovascular risk; Cardiovascular diseases; Cardiovascular disease; Caloric intake; Body weight; Body mass; Body fat; Blood pressure; Blood; Biomarkers; Biological marker; Article; Antithrombocytic agent; Antilipemic agent; Antihypertensive agent; Anthropometry; Alcohol drinking; Alcohol consumption; Alcohol; Aged, 80 and over; Aged; Age; Adult
Abstract: Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevencion con Dieta Mediterranea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 mu g/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 mu g/mg (-5.54, -0.71), p-value = 0.016 and -3.03 mu g/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Record's date: 2025-02-18
Journal volume: 13
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/13/8/2883
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 13 (8): 2883-
APA: Dominguez-Lopez, Ines; Parilli-Moser, Isabella; Arancibia-Riveros, Camila; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel Angel; Ortega-Azorin, Car (2021). Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol. Nutrients, 13(8), 2883-. DOI: 10.3390/nu13082883
Article's DOI: 10.3390/nu13082883
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV