Articles producció científica> Bioquímica i Biotecnologia

Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol

  • Identification data

    Identifier: imarina:9226633
    Authors:
    Dominguez-Lopez, InesParilli-Moser, IsabellaArancibia-Riveros, CamilaTresserra-Rimbau, AnnaMartinez-Gonzalez, Miguel AngelOrtega-Azorin, CarolinaSalas-Salvado, JordiCastaner, OlgaLapetra, JoseAros, FernandoFiol, MiquelSerra-Majem, LluisPinto, XavierGomez-Gracia, EnriqueRos, EmilioLamuela-Raventos, Rosa M.Estruch, Ramon
    Abstract:
    Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevencion con Dieta Mediterranea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 mu g/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 mu g/mg (-5.54, -0.71), p-value = 0.016 and -3.03 mu g/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
  • Others:

    Author, as appears in the article.: Dominguez-Lopez, Ines; Parilli-Moser, Isabella; Arancibia-Riveros, Camila; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel Angel; Ortega-Azorin, Carolina; Salas-Salvado, Jordi; Castaner, Olga; Lapetra, Jose; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Gomez-Gracia, Enrique; Ros, Emilio; Lamuela-Raventos, Rosa M.; Estruch, Ramon;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Wine Waist to height ratio Waist circumference Very elderly Vegetable consumption Urine sampling Urine level Urine Tartrates Tartaric acid Tandem mass spectrometry Sirtuin 1 Resveratrol Red wine Randomized controlled trials as topic Randomized controlled trial (topic) Randomized controlled trial Questionnaire Predimed Polyphenols Physical activity People by smoking status Oral antidiabetic agent Multicenter study Middle aged Menopause Mediterranean diet Male Major clinical study Low density lipoprotein cholesterol level Low density lipoprotein cholesterol Liquid chromatography-mass spectrometry Liquid chromatography Lipid profile Insulin treatment Insulin Hydroxymethylglutaryl coenzyme a reductase inhibitor Humans Human Heart disease risk factors Health Glucose blood level Glucose Fruit consumption Female Electrospray mass spectrometry Educational status Drinking behavior Diuretic agent Dipeptidyl carboxypeptidase inhibitor Cross-sectional study Cross-sectional studies Coronary-heart-disease Controlled study Consumption Clinical trial Cholesterol, ldl Cholesterol blood level Cholesterol Cardiovascular risk-factors Cardiovascular risk Cardiovascular diseases Cardiovascular disease Caloric intake Body weight Body mass Body fat Blood pressure Blood Biomarkers Biological marker Article Antithrombocytic agent Antilipemic agent Antihypertensive agent Anthropometry Alcohol drinking Alcohol consumption Alcohol Aged, 80 and over Aged Age Adult
    Abstract: Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevencion con Dieta Mediterranea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 mu g/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 mu g/mg (-5.54, -0.71), p-value = 0.016 and -3.03 mu g/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-07-27
    Journal volume: 13
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/8/2883
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (8):
    APA: Dominguez-Lopez, Ines; Parilli-Moser, Isabella; Arancibia-Riveros, Camila; Tresserra-Rimbau, Anna; Martinez-Gonzalez, Miguel Angel; Ortega-Azorin, Car (2021). Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol. Nutrients, 13(8), -. DOI: 10.3390/nu13082883
    Article's DOI: 10.3390/nu13082883
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Wine
    Waist to height ratio
    Waist circumference
    Very elderly
    Vegetable consumption
    Urine sampling
    Urine level
    Urine
    Tartrates
    Tartaric acid
    Tandem mass spectrometry
    Sirtuin 1
    Resveratrol
    Red wine
    Randomized controlled trials as topic
    Randomized controlled trial (topic)
    Randomized controlled trial
    Questionnaire
    Predimed
    Polyphenols
    Physical activity
    People by smoking status
    Oral antidiabetic agent
    Multicenter study
    Middle aged
    Menopause
    Mediterranean diet
    Male
    Major clinical study
    Low density lipoprotein cholesterol level
    Low density lipoprotein cholesterol
    Liquid chromatography-mass spectrometry
    Liquid chromatography
    Lipid profile
    Insulin treatment
    Insulin
    Hydroxymethylglutaryl coenzyme a reductase inhibitor
    Humans
    Human
    Heart disease risk factors
    Health
    Glucose blood level
    Glucose
    Fruit consumption
    Female
    Electrospray mass spectrometry
    Educational status
    Drinking behavior
    Diuretic agent
    Dipeptidyl carboxypeptidase inhibitor
    Cross-sectional study
    Cross-sectional studies
    Coronary-heart-disease
    Controlled study
    Consumption
    Clinical trial
    Cholesterol, ldl
    Cholesterol blood level
    Cholesterol
    Cardiovascular risk-factors
    Cardiovascular risk
    Cardiovascular diseases
    Cardiovascular disease
    Caloric intake
    Body weight
    Body mass
    Body fat
    Blood pressure
    Blood
    Biomarkers
    Biological marker
    Article
    Antithrombocytic agent
    Antilipemic agent
    Antihypertensive agent
    Anthropometry
    Alcohol drinking
    Alcohol consumption
    Alcohol
    Aged, 80 and over
    Aged
    Age
    Adult
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenha
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