Author, as appears in the article.: Rubio, Laura; Romero, Maria Paz; Sola, Rosa; Motilva, Maria Jose; Clifford, Michael N.; Macia, Alba;
Department: Medicina i Cirurgia
URV's Author/s: Solà Alberich, Rosa Maria
Keywords: Red-fleshed apple Phenolic-acids Metabolites Healthy-volunteers Coffee Catechol-o-methyl transferase Caffeoylquinic acids Blood-pressure Bioavailability Apples 3?-methoxycinnamic acid-4?sulfate 3?- / 4?-methylation ratio 3 '-methoxycinnamic acid-4 ' sulfate 3 '-4 '-methylation ratio
Abstract: Introduction: It has been reported that the phenolic metabolite 3 '-methoxycinnamic acid-4 '-sulfate generated from 5-O-caffeoylquinic acid may have potential benefits in human health. However, the variation in 3 '- and 4 '-methylation of 3 ',4 '-dihydroxycinnamic acid and its impact on the yield of this sulfate metabolite is unclear and has been poorly studied.Methods and Results: To address this aim, the excreted 3 '-methoxy and 4 '-methoxy metabolites in urine samples (24-h) are determined in 14 volunteers after an acute intake of 80 g of red-fleshed apple (RFA) or white-fleshed apple (WFA). These methoxy metabolites are also determined in the same volunteers in a second acute intake after a 6-week sustained consumption of the same products.Conclusion: Seven 3 '-methoxy and seven 4 '-methoxy metabolites are determined, i.e., the free cinnamic and corresponding phenylpropanoic acid, plus their sulfate, glucuronide, and glycine conjugates. In only six volunteers, five females and one male, is 4 '-methylation preferred over 3 '-methylation, but it is observed that an individual ' s 3 '- : 4 '-methylation ratio can change over time, and that the yield of 3 '-methoxycinnamic acid-4 '-sulfate is extremely variable, ranging from undetectable to 71% of the total C-6-C-3 metabolites excreted, and any benefit accruing from this metabolite will not necessarily be available to all consumers.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: rosa.sola@urv.cat
Author identifier: 0000-0002-8359-235X
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 65 (19):
APA: Rubio, Laura; Romero, Maria Paz; Sola, Rosa; Motilva, Maria Jose; Clifford, Michael N.; Macia, Alba; (2021). Variation in the Methylation of Caffeoylquinic Acids and Urinary Excretion of 3 '-methoxycinnamic acid-4 '-Sulfate After Apple Consumption by Volunteers. Molecular Nutrition & Food Research, 65(19), -. DOI: 10.1002/mnfr.202100471
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV