Author, as appears in the article.: Osuna-Prieto, Francisco J.; Martinez-Tellez, Borja; Ortiz-Alvarez, Lourdes; Di, Xinyu; Jurado-Fasoli, Lucas; Xu, Huiwen; Ceperuelo-Mallafre, Victoria; Nunez-Roa, Catalina; Kohler, Isabelle; Segura-Carretero, Antonio; Garcia-Lario, Jose, V; Gil, Angel; Aguilera, Concepcion M.; Llamas-Elvira, Jose M.; Rensen, Patrick C. N.; Vendrell, Joan; Ruiz, Jonatan R.; Fernandez-Veledo, Sonia;

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Vendrell Ortega, Juan José

Keywords: Visceral adiposity Triggers Succinate Oxylipins Obesity Metabolism Macrophages Inflammation Fatty-acids Cells Brown adipose-tissue Accumulation

Abstract: BackgroundSuccinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory and metabolic disorders in middle-aged adults. The relationship between plasma succinate levels and cardiovascular disease (CVD) risk in young adults is unknown.MethodsCross-sectional study in 100 (65% women) individuals aged 18-25 years from the ACTIvating Brown Adipose Tissue through Exercise (ACTIBATE) study cohort. CVD risk factors, body composition, dietary intake, basal metabolic rate, and cardiorespiratory fitness were assessed by routine methods. Plasma succinate was measured with an enzyme-based assay. Brown adipose tissue (BAT) was evaluated by positron emission tomography, and circulating oxylipins were assessed by targeted metabolomics. Fecal microbiota composition was analyzed in a sub-sample.ResultsIndividuals with higher succinate levels had higher levels of visceral adipose tissue (VAT) mass (+42.5%), triglycerides (+63.9%), C-reactive protein (+124.2%), diastolic blood pressure (+5.5%), and pro-inflammatory omega-6 oxylipins than individuals with lower succinate levels. Succinate levels were also higher in metabolically unhealthy individuals than in healthy overweight/obese peers. Succinate levels were not associated with BAT volume or activity or with fecal microbiota composition and diversity.ConclusionsPlasma succinate levels are linked to a specific pro-inflammatory omega-6 signature pattern and higher VAT levels, and seem to reflect the cardiovascular status of young adults.

Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: sonia.fernandez@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat

Author identifier: 0000-0003-2906-3788 0000-0002-4460-9761 0000-0002-6994-6115

Record's date: 2023-10-07

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01333-3

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Cardiovascular Diabetology. 20 (1):

APA: Osuna-Prieto, Francisco J.; Martinez-Tellez, Borja; Ortiz-Alvarez, Lourdes; Di, Xinyu; Jurado-Fasoli, Lucas; Xu, Huiwen; Ceperuelo-Mallafre, Victoria; (2021). Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults. Cardiovascular Diabetology, 20(1), -. DOI: 10.1186/s12933-021-01333-3

Article's DOI: 10.1186/s12933-021-01333-3

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications