Author, as appears in the article.: Osuna-Prieto, Francisco J; Martinez-Tellez, Borja; Ortiz-Alvarez, Lourdes; Di, Xinyu; Jurado-Fasoli, Lucas; Xu, Huiwen; Ceperuelo-Mallafre, Victoria; Nunez-Roa, Catalina; Kohler, Isabelle; Segura-Carretero, Antonio; Garcia-Lario, Jose, V; Gil, Angel; Aguilera, Concepcion M; Llamas-Elvira, Jose M; Rensen, Patrick C N; Vendrell, Joan; Ruiz, Jonatan R; Fernandez-Veledo, Sonia
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Vendrell Ortega, Juan José
Keywords: Young adult; Visceral adiposity; Up-regulation; Triglycerides; Triggers; Succinic acid; Succinate; Risk assessment; Randomized controlled trials as topic; Oxylipins; Obesity; Metabolism; Male; Macrophages; Intra-abdominal fat; Inflammation mediators; Inflammation; Humans; Heart disease risk factors; Gastrointestinal microbiome; Female; Fatty-acids; Cross-sectional studies; Cells; Cardiovascular diseases; C-reactive protein; Brown adipose-tissue; Blood pressure; Biomarkers; Age factors; Adult; Adolescent; Adiposity; Accumulation
Abstract: BackgroundSuccinate is produced by both host and microbiota, with a key role in the interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory and metabolic disorders in middle-aged adults. The relationship between plasma succinate levels and cardiovascular disease (CVD) risk in young adults is unknown.MethodsCross-sectional study in 100 (65% women) individuals aged 18-25 years from the ACTIvating Brown Adipose Tissue through Exercise (ACTIBATE) study cohort. CVD risk factors, body composition, dietary intake, basal metabolic rate, and cardiorespiratory fitness were assessed by routine methods. Plasma succinate was measured with an enzyme-based assay. Brown adipose tissue (BAT) was evaluated by positron emission tomography, and circulating oxylipins were assessed by targeted metabolomics. Fecal microbiota composition was analyzed in a sub-sample.ResultsIndividuals with higher succinate levels had higher levels of visceral adipose tissue (VAT) mass (+42.5%), triglycerides (+63.9%), C-reactive protein (+124.2%), diastolic blood pressure (+5.5%), and pro-inflammatory omega-6 oxylipins than individuals with lower succinate levels. Succinate levels were also higher in metabolically unhealthy individuals than in healthy overweight/obese peers. Succinate levels were not associated with BAT volume or activity or with fecal microbiota composition and diversity.ConclusionsPlasma succinate levels are linked to a specific pro-inflammatory omega-6 signature pattern and higher VAT levels, and seem to reflect the cardiovascular status of young adults.
Thematic Areas: Saúde coletiva; Medicina ii; Medicina i; Internal medicine; Interdisciplinar; Farmacia; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Educação física; Ciências biológicas ii; Ciências biológicas i; Cardiology and cardiovascular medicine; Cardiac & cardiovascular systems; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: victoria.ceperuelo@urv.cat; sonia.fernandez@urv.cat; jvortega@iispv.cat
Record's date: 2025-01-08
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01333-3
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Cardiovascular Diabetology. 20 (1): 151-
APA: Osuna-Prieto, Francisco J; Martinez-Tellez, Borja; Ortiz-Alvarez, Lourdes; Di, Xinyu; Jurado-Fasoli, Lucas; Xu, Huiwen; Ceperuelo-Mallafre, Victoria; (2021). Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults. Cardiovascular Diabetology, 20(1), 151-. DOI: 10.1186/s12933-021-01333-3
Article's DOI: 10.1186/s12933-021-01333-3
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV