Articles producció científica> Medicina i Cirurgia

COVID-19 in hospitalized HIV-positive and HIV-negative patients: A matched study

  • Identification data

    Identifier: imarina:9226938
    Authors:
    Diez, CristinaDel Romero-Raposo, JorgeMican, RafaelLopez, Juan C.Blanco, Jose R.Calzado, SoniaSamperiz, GloriaPortilla, JoaquinGarcia-Fraile, Lucio J.Gutierrez, FelixGomez-Sirvent, Juan L.Suarez-Garcia, InesAmador, ConchaNovella, MariaArribas, Jose R.Moreno, SantiagoGonzalez-Garcia, JuanJarrin, InmaculadaBerenguer, JuanCoRIS
    Abstract:
    Objectives We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/mu L. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.
  • Others:

    Author, as appears in the article.: Diez, Cristina; Del Romero-Raposo, Jorge; Mican, Rafael; Lopez, Juan C.; Blanco, Jose R.; Calzado, Sonia; Samperiz, Gloria; Portilla, Joaquin; Garcia-Fraile, Lucio J.; Gutierrez, Felix; Gomez-Sirvent, Juan L.; Suarez-Garcia, Ines; Amador, Concha; Novella, Maria; Arribas, Jose R.; Moreno, Santiago; Gonzalez-Garcia, Juan; Jarrin, Inmaculada; Berenguer, Juan;CoRIS
    Department: Medicina i Cirurgia
    URV's Author/s: Peraire Forner, José Joaquin
    Keywords: Sars-cov-2 Hiv Covid-19 Coronavirus Cohort
    Abstract: Objectives We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/mu L. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.
    Thematic Areas: Psicología Pharmacology (medical) Medicina ii Medicina i Infectious diseases Health policy Ciências biológicas iii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joaquim.peraire@urv.cat
    Author identifier: 0000-0001-7808-5479
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.13145
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Hiv Medicine. 22 (9): 867-876
    APA: Diez, Cristina; Del Romero-Raposo, Jorge; Mican, Rafael; Lopez, Juan C.; Blanco, Jose R.; Calzado, Sonia; Samperiz, Gloria; Portilla, Joaquin; Garcia- (2021). COVID-19 in hospitalized HIV-positive and HIV-negative patients: A matched study. Hiv Medicine, 22(9), 867-876. DOI: 10.1111/hiv.13145
    Article's DOI: 10.1111/hiv.13145
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Health Policy,Infectious Diseases,Pharmacology (Medical)
    Sars-cov-2
    Hiv
    Covid-19
    Coronavirus
    Cohort
    Psicología
    Pharmacology (medical)
    Medicina ii
    Medicina i
    Infectious diseases
    Health policy
    Ciências biológicas iii
    Ciências biológicas i
    Biotecnología
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