Author, as appears in the article.: Rodriguez-Andrade, Ernesto; Cano-Lira, Jose F.; Wiederhold, Nathan; Perez-Cantero, Alba; Guarro, Josep; Stchigel, Alberto M.;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Cano Lira, José Francisco / Guarro Artigas, Josep / PÉREZ CANTERO, ALBA / Rodríguez Andrade, Ernesto / Stchigel Glikman, Alberto Miguel
Keywords: Taxonomy Sp-nov. Phylogeny Onygenales Onychomycosis Onychocola-canadensis New taxa Nail Malbranchea Keratinophilic fungi Infection Genus Clinical fungi Auxarthron Arachnomycetales Antifungals
Abstract: The fungi of the order Onygenales can cause important human infections; however, their taxonomy and worldwide occurrence is still little known. We have studied and identified a representative number of clinical fungi belonging to that order from a reference laboratory in the USA. A total of 22 strains isolated from respiratory tract (40%) and human skin and nails (27.2%) showed a malbranchea-like morphology. Six genera were phenotypically and molecularly identified, i.e. Auxarthron/Malbranchea (68.2%), Arachnomyces (9.1%), Spiromastigoides (9.1%), and Currahmyces (4.5%), and two newly proposed genera (4.5% each). Based on the results of the phylogenetic study, we synonymized Auxarthron with Malbranchea, and erected two new genera: Pseudoarthropsis and Pseudomalbranchea. New species proposed are: Arachnomyces bostrychodes, A. graciliformis, Currahmyces sparsispora, Malbranchea gymnoascoides, M. multiseptata, M. stricta, Pseudoarthropsis crassispora, Pseudomalbranchea gemmata, and Spiromastigoides geomycoides, along with a new combination for Malbranchea gypsea. The echinocandins showed the highest in vitro antifungal activity against the studied isolates, followed by terbinafine and posaconazole; in contrast, amphotericin B, fluconazole, itraconazole and 5-fluorocytosine were less active or lacked in vitro activity against these fungi.
Thematic Areas: Plant science Mycology Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas i Ciências agrárias i Biodiversidade Agricultural and biological sciences (miscellaneous)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josep.guarro@urv.cat jose.cano@urv.cat albertomiguel.stchigel@urv.cat
Author identifier: 0000-0002-7839-7568 0000-0003-4495-4394 0000-0003-3987-7996
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://imafungus.biomedcentral.com/articles/10.1186/s43008-021-00075-x
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Ima Fungus. 12 (1):
APA: Rodriguez-Andrade, Ernesto; Cano-Lira, Jose F.; Wiederhold, Nathan; Perez-Cantero, Alba; Guarro, Josep; Stchigel, Alberto M.; (2021). A revision of malbranchea-like fungi from clinical specimens in the United States of America reveals unexpected novelty. Ima Fungus, 12(1), -. DOI: 10.1186/s43008-021-00075-x
Article's DOI: 10.1186/s43008-021-00075-x
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV