Articles producció científica> Bioquímica i Biotecnologia

Gut microbiome modulation and faecal microbiota transplantation following allogenic hematopoietic stem cell transplantation

  • Identification data

    Identifier: imarina:9228605
    Authors:
    Kaźmierczak-Siedlecka KSkonieczna-żydecka KBiliński JRoviello GIannone LFAtzeni ASobocki BKPołom K
    Abstract:
    Nowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute to the development of gut microbiota imbalance, gut-barrier disruption, and increased intestinal permeability. In the present narrative review, the crosstalk between gut microbiota products and intestinal homeostasis is discussed. Notably, gut-microbiota-related aspects have an impact on patients’ clinical outcomes and overall survival. In accordance with the most recent published data, gut microbiota is crucial for the treatment effectiveness of many diseases, not only gastrointestinal cancers but also hematologic malignancies. Therefore, it is necessary to indicate a therapeutic method allowing to modulate gut microbiota in HSCT recipients. Currently, fecal microbiota transplantation (FMT) is the most innovative method used to alter/restore gut microbiota composition, as well as modulate its activity. Despite the fact that some previous data have shown promising results, the knowledge regarding FMT in HSCT is still strongly limited, except for the treatment of Clostridium difficile infection. Additionally, administration of prebiotics, probiotics, synbiotics, and postbiotics can also modify gut microbiota; however, this strategy should be considered carefully due to the high risk of fungemia/septicemia (especially in case of fungal probiotics)..
  • Others:

    Author, as appears in the article.: Kaźmierczak-Siedlecka K; Skonieczna-żydecka K; Biliński J; Roviello G; Iannone LF; Atzeni A; Sobocki BK; Połom K
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Atzeni, Alessandro
    Keywords: Versus-host-disease Synbiotics Probiotics Prebiotics Postbiotics Intestinal integrity Gut microbiota Fecal microbiota transplantation Allogenic hematopoietic stem cell transplantation synbiotics recurrent probiotics prebiotics postbiotics pediatric-patients metabolites intestinal integrity gut microbiota fecal microbiota transplantation cost-effectiveness analysis colonization clostridium-difficile infection chemotherapy bacteremia
    Abstract: Nowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute to the development of gut microbiota imbalance, gut-barrier disruption, and increased intestinal permeability. In the present narrative review, the crosstalk between gut microbiota products and intestinal homeostasis is discussed. Notably, gut-microbiota-related aspects have an impact on patients’ clinical outcomes and overall survival. In accordance with the most recent published data, gut microbiota is crucial for the treatment effectiveness of many diseases, not only gastrointestinal cancers but also hematologic malignancies. Therefore, it is necessary to indicate a therapeutic method allowing to modulate gut microbiota in HSCT recipients. Currently, fecal microbiota transplantation (FMT) is the most innovative method used to alter/restore gut microbiota composition, as well as modulate its activity. Despite the fact that some previous data have shown promising results, the knowledge regarding FMT in HSCT is still strongly limited, except for the treatment of Clostridium difficile infection. Additionally, administration of prebiotics, probiotics, synbiotics, and postbiotics can also modify gut microbiota; however, this strategy should be considered carefully due to the high risk of fungemia/septicemia (especially in case of fungal probiotics)..
    Thematic Areas: Oncology Medicina iii Cancer research
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat
    Author identifier: 0000-0002-1804-8606 0000-0002-1804-8606
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Cancers. 13 (18):
    APA: Kaźmierczak-Siedlecka K; Skonieczna-żydecka K; Biliński J; Roviello G; Iannone LF; Atzeni A; Sobocki BK; Połom K (2021). Gut microbiome modulation and faecal microbiota transplantation following allogenic hematopoietic stem cell transplantation. Cancers, 13(18), -. DOI: 10.3390/cancers13184665
    Article's DOI: 10.3390/cancers13184665
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Cancer Research,Oncology
    Versus-host-disease
    Synbiotics
    Probiotics
    Prebiotics
    Postbiotics
    Intestinal integrity
    Gut microbiota
    Fecal microbiota transplantation
    Allogenic hematopoietic stem cell transplantation
    synbiotics
    recurrent
    probiotics
    prebiotics
    postbiotics
    pediatric-patients
    metabolites
    intestinal integrity
    gut microbiota
    fecal microbiota transplantation
    cost-effectiveness analysis
    colonization
    clostridium-difficile infection
    chemotherapy
    bacteremia
    Oncology
    Medicina iii
    Cancer research
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