Author, as appears in the article.: Soldevila-Domenech, Natalia; Forcano, Laura; Vintro-Alcaraz, Cristina; Cuenca-Royo, Aida; Pinto, Xavier; Jimenez-Murcia, Susana; Garcia-Gavilan, Jesus F.; Nishi, Stephanei K.; Babio, Nancy; Gomis-Gonzalez, Maria; Corella, Dolores; V. Sorli, Jose; Fernandez-Carrion, Rebeca; Martinez-Gonzalez, Miguel Angel; Marti, Amelia; Salas-Salvado, Jordi; Castaner, Olga; Fernandez-Aranda, Fernando; de la Torre, Rafael;
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Nishi, Stephanie Kimiko / Salas Salvadó, Jorge
Keywords: Wellbeing Volume Visuoconstructive praxis Verbal memory Therapy effect Symbol digit modalities test Short form 36 Sex difference Rey osterrieth complex figure test Rey auditory verbal learning test Recall Reaction time Quality of life Prevention Prevalence Physical-activity Physical activity Overweight Older-adults Obesity Obese individuals Nutrition Neuropsychological test Mini mental state examination Metabolic syndrome x Metabolic syndrome Mental function Memory Mediterranean diet Maximum-likelihood Male Longitudinal study Lifestyle modification Iowa gambling task Intervention Intelligence quotient Human Follow up Female Executive function Dietary compliance Depression Decline Correlational study Controlled study Cognition Clinical outcome Cardiovascular disease Brain function Body weight loss Body mass Behavior assessment Beck depression inventory Attention Article Aged Adherence
Abstract: Background & aims: Some cognitive profiles might facilitate successful weight loss and its maintenance. Also, weight reductions may result in cognitive benefits. However, little work to date has examined the interactions between cognition and weight changes in the context of interventions with the Mediterranean diet (MedDiet). We studied the within-subject longitudinal relationships between cognition, body mass index (BMI), physical activity (PA), and quality of life (QoL), in older adults following a MedDiet.Methods: The PREDIMED-Plus is a primary prevention trial testing the effect of a lifestyle intervention program with an energy-restricted MedDiet (er-MedDiet), weight-loss goals and PA promotion on cardiovascular disease. The PREDIMED-Plus-Cognition sub-study included 487 participants (50% women, mean age 65.2 +/- 4.7 years), with overweight/obesity, metabolic syndrome and normal cognitive performance at baseline. A comprehensive neurocognitive test battery was administered at baseline and after 1 and 3 years.Results: Baseline higher performance in verbal memory (OR = 1.5; 95%CI 1.0, 2.1), visuoconstructive praxis and attention (OR = 1.5; 95%CI 0.9, 2.3), and inhibition (OR = 1.3; 95%CI 0.9,1.9) were associated with a higher odd of achieving at least 8% weight loss after 3 years follow-up in participants randomized to the intervention group. There were moderate improvements in specific tests of memory and executive functions during follow-up. Higher adherence to the er-MedDiet was associated with greater improvements in memory. Women exhibited lower rates of change in global cognition, PA and QoL. Moreover, improvements in memory correlated with reductions in BMI after 1 year (beta(STD) = -0.14) and with improvements in PA after 3 years (beta(STD) = 0.13). Finally, participants who experienced greater improvements in executive functions and global cognition also experienced greater improvements in their QoL.Conclusions: This study refines the understanding of the determinants and mutual interrelationships between longitudinally-assessed cognitive performance and weight loss, adding further evidence to the cognitive benefits associated with better adherence to a MedDiet. Our results also suggest that weight loss interventions tailored to the cognitive profile and gender of participants are promising avenues for future studies. (C) 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jesusfrancisco.garcia@urv.cat stephanie.nishi@urv.cat jesusfrancisco.garcia@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(21)00354-X/fulltext
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Nutrition. 40 (9): 5221-5237
APA: Soldevila-Domenech, Natalia; Forcano, Laura; Vintro-Alcaraz, Cristina; Cuenca-Royo, Aida; Pinto, Xavier; Jimenez-Murcia, Susana; Garcia-Gavilan, Jesus (2021). Interplay between cognition and weight reduction in individuals following a Mediterranean Diet: Three-year follow-up of the PREDIMED-Plus trial. Clinical Nutrition, 40(9), 5221-5237. DOI: 10.1016/j.clnu.2021.07.020
Article's DOI: 10.1016/j.clnu.2021.07.020
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV