Author, as appears in the article.: Canyelles, Marina; Garcia-Osuna, Alvaro; Junza, Alexandra; Yanes, Oscar; Puig, Nuria; Ordonez-Llanos, Jordi; Sionis, Alessandro; Sans-Rosello, Jordi; Alquezar-Arbe, Aitor; Santos, David; Rotllan, Noemi; Julve, Josep; Tondo, Mireia; Escola-Gil, Joan Carles; Blanco-Vaca, Francisco
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Junza Martínez, Alexandra / Yanes Torrado, Óscar
Keywords: Trimethyllysine Trimethylamine-n-oxide Trimethylamine n-oxide Myocardial infarction Macrophages Hdl-mediated efflux trimethyllysine trimethylamine n-oxide risk pathway myocardial infarction management macrophages l-carnitine guidelines functionality events disease cardiovascular mortality
Abstract: Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with cardiovascular death, but their interactions with HDL-mediated cholesterol efflux remain unclear. We aimed to determine the associations between APOB depleted plasma-mediated macrophage cholesterol efflux and plasma TMAO, γBB, and TML concentrations and explore their association with two-year follow-up mortality in patients with acute ST-elevation myocardial infarction (STEMI) and unstable angina (UA). Baseline and ATP-binding cassette transporter ABCA1 and ABCG1 (ABCA1/G1)-mediated macrophage cholesterol efflux to APOB-depleted plasma was decreased in patients with STEMI, and the latter was further impaired in those who died during follow-up. Moreover, the circulating concentrations of TMAO, γBB, and TML were higher in the deceased STEMI patients when compared with the STEMI survivors or UA patients. However, after statistical adjustment, only ABCA1/G1-mediated macrophage cholesterol efflux remained significantly associated with mortality. Furthermore, neither the TMAO, γBB, nor TML levels altered the HDL-mediated macrophage cholesterol efflux in vitro. We conclude that impaired ABCA1/G1-mediated macrophage cholesterol efflux is independently associated with mortality at follow-up in STEMI patients.
Thematic Areas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: oscar.yanes@urv.cat alexandra.junza@urv.cat
Author identifier: 0000-0003-3695-7157 0000-0001-7205-0419
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2227-9059/9/10/1336
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Biomedicines. 9 (10): 1336-
APA: Canyelles, Marina; Garcia-Osuna, Alvaro; Junza, Alexandra; Yanes, Oscar; Puig, Nuria; Ordonez-Llanos, Jordi; Sionis, Alessandro; Sans-Rosello, Jordi; (2021). The capacity of apob-depleted plasma in inducing atp-binding cassette a1/g1-mediated macrophage cholesterol efflux—but not gut microbial-derived metabolites—is independently associated with mortality in patients with st-segment elevation myocardial infarction. Biomedicines, 9(10), 1336-. DOI: 10.3390/biomedicines9101336
Article's DOI: 10.3390/biomedicines9101336
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV