Articles producció científica> Química Física i Inorgànica

Protein corona modulates interaction of spiky nanoparticles with lipid bilayers

  • Identification data

    Identifier: imarina:9230181
    Authors:
    Fleury, Jean-BaptisteWerner, MarcoLe Guevel, XavierBaulin, Vladimir A.
    Abstract:
    The impact of protein corona on the interactions of nanoparticles (NPs) with cells remains an open ques-tion. This question is particularly relevant to NPs which sizes, ranging from tens to hundreds nanometers, are comparable to the sizes of most abundant proteins in plasma. Protein sizes match with typical thick-ness of various coatings and ligands layers, usually present at the surfaces of larger NPs. Such size match may affect the properties and the designed function of NPs. We offer a direct demonstration of how pro-tein corona can dramatically change the interaction mode between NPs and lipid bilayers. To this end, we choose the most extreme case of NP surface modification: nanostructures in the form of rigid spikes of 10-20 nm length at the surface of gold nanoparticles. In the absence of proteins we observe the formation of reversible pores when spiky NPs adsorb on lipid bilayers. In contrast, the presence of bovine serum albumin (BSA) proteins adsorbed at the surface of spiked NPs, effectively reduces the length of spikes exposed to the interaction with lipid bilayers. Thus, protein corona changes qualitatively the dynamics of pore formation, which is completely suppressed at high protein concentrations. These results suggest that protein corona can not only be critical for interaction of NPs with membranes, it may change their mode of interaction, thus offsetting the role of surface chemistry and ligands. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • Others:

    Author, as appears in the article.: Fleury, Jean-Baptiste; Werner, Marco; Le Guevel, Xavier; Baulin, Vladimir A.;
    Department: Química Física i Inorgànica
    URV's Author/s: Baulin, Vladimir
    Keywords: Size Quantum dots Protein corona Pore formation Platform Nanostars Nanoparticles Microfluidics Lipid bilayers Induced permeability Compact Cell-interactions Adsorption
    Abstract: The impact of protein corona on the interactions of nanoparticles (NPs) with cells remains an open ques-tion. This question is particularly relevant to NPs which sizes, ranging from tens to hundreds nanometers, are comparable to the sizes of most abundant proteins in plasma. Protein sizes match with typical thick-ness of various coatings and ligands layers, usually present at the surfaces of larger NPs. Such size match may affect the properties and the designed function of NPs. We offer a direct demonstration of how pro-tein corona can dramatically change the interaction mode between NPs and lipid bilayers. To this end, we choose the most extreme case of NP surface modification: nanostructures in the form of rigid spikes of 10-20 nm length at the surface of gold nanoparticles. In the absence of proteins we observe the formation of reversible pores when spiky NPs adsorb on lipid bilayers. In contrast, the presence of bovine serum albumin (BSA) proteins adsorbed at the surface of spiked NPs, effectively reduces the length of spikes exposed to the interaction with lipid bilayers. Thus, protein corona changes qualitatively the dynamics of pore formation, which is completely suppressed at high protein concentrations. These results suggest that protein corona can not only be critical for interaction of NPs with membranes, it may change their mode of interaction, thus offsetting the role of surface chemistry and ligands. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Thematic Areas: Surfaces, coatings and films Química Nutrição Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Electronic, optical and magnetic materials Economia Colloid and surface chemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, physical Biotecnología Biomaterials Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: vladimir.baulin@urv.cat
    Author identifier: 0000-0003-2086-4271
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0021979721009218?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Colloid And Interface Science. 603 550-558
    APA: Fleury, Jean-Baptiste; Werner, Marco; Le Guevel, Xavier; Baulin, Vladimir A.; (2021). Protein corona modulates interaction of spiky nanoparticles with lipid bilayers. Journal Of Colloid And Interface Science, 603(), 550-558. DOI: 10.1016/j.jcis.2021.06.047
    Article's DOI: 10.1016/j.jcis.2021.06.047
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Biomaterials,Chemistry, Physical,Colloid and Surface Chemistry,Electronic, Optical and Magnetic Materials,Surfaces, Coatings and Films
    Size
    Quantum dots
    Protein corona
    Pore formation
    Platform
    Nanostars
    Nanoparticles
    Microfluidics
    Lipid bilayers
    Induced permeability
    Compact
    Cell-interactions
    Adsorption
    Surfaces, coatings and films
    Química
    Nutrição
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Electronic, optical and magnetic materials
    Economia
    Colloid and surface chemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, physical
    Biotecnología
    Biomaterials
    Biodiversidade
    Astronomia / física
  • Documents:

  • Cerca a google

    Search to google scholar