Articles producció científica> Enginyeria Química

Thiolated amphiphilic β-cyclodextrin-decorated gold colloids: Synthesis, supramolecular nanoassemblies and controlled release of dopamine

  • Identification data

    Identifier: imarina:9230195
    Authors:
    Trapani, MariachiaraScala, AngelaMineo, Placido GPistone, AlessandroDiaz-Moscoso, AlejandroFragoso, AlexScolaro, Luigi MonsuMazzaglia, Antonino
    Abstract:
    We report a hybrid nanoassembly based on gold colloids decorated with a new thiolated amphiphilic cyclodextrin complexing dopamine (AuNPs@SC16SH/DA). The novel amphiphilic β-cyclodextrin SC16SH, bearing on average one thiol group at the end of an oligoethylene glycol chain per CyD unit, was obtained in a multi-step synthesis and fully characterized by NMR spectroscopy and MALDI analysis. The AuNPs@SC16SH hybrid assembly was prepared by mixing AuNPs and SC16SH in aqueous solution and investigated by UV/Vis and TEM measurements. The AuNPs@SC16SH/DA supramolecular assembly, bearing both thiol-stabilized gold nanoparticles and the neurotransmitter dopamine, has been conceived as stimuli-responsive delivery system able to control the release of dopamine upon proper stimuli. Two redox functionalities (i.e. the Au-S bond and the redox behaviour of dopamine) have been exploited to detach SC16SH/DA complex from the AuNPs@SC16SH/DA progenitor platform, using dithiothreitol (DTT), and to detect the complex by cyclic voltammetry (CV). Following, dopamine was finally released from the SC16SH/DA assembly upon treatment with Brij® S20 and the free dopamine was monitored by CV. Overall, our hybrid nanoassemblies turned out to be able to release dopamine, upon combined action of redox and digestion agents in medium emulating biological environment.
  • Others:

    Author, as appears in the article.: Trapani, Mariachiara; Scala, Angela; Mineo, Placido G; Pistone, Alessandro; Diaz-Moscoso, Alejandro; Fragoso, Alex; Scolaro, Luigi Monsu; Mazzaglia, Antonino
    Department: Enginyeria Química
    URV's Author/s: Fragoso Sierra, Alex
    Keywords: Nanovesicles Hybrid assemblies Gold colloids Dopamine Cyclic voltammetry Blood-brain-barrier Amphiphilic cyclodextrins vesicles polydisperse polymers perspectives particles nanovesicles nanostructures nanoparticles hybrid assemblies gold colloids dopamine delivery cyclic voltammetry complexes blends
    Abstract: We report a hybrid nanoassembly based on gold colloids decorated with a new thiolated amphiphilic cyclodextrin complexing dopamine (AuNPs@SC16SH/DA). The novel amphiphilic β-cyclodextrin SC16SH, bearing on average one thiol group at the end of an oligoethylene glycol chain per CyD unit, was obtained in a multi-step synthesis and fully characterized by NMR spectroscopy and MALDI analysis. The AuNPs@SC16SH hybrid assembly was prepared by mixing AuNPs and SC16SH in aqueous solution and investigated by UV/Vis and TEM measurements. The AuNPs@SC16SH/DA supramolecular assembly, bearing both thiol-stabilized gold nanoparticles and the neurotransmitter dopamine, has been conceived as stimuli-responsive delivery system able to control the release of dopamine upon proper stimuli. Two redox functionalities (i.e. the Au-S bond and the redox behaviour of dopamine) have been exploited to detach SC16SH/DA complex from the AuNPs@SC16SH/DA progenitor platform, using dithiothreitol (DTT), and to detect the complex by cyclic voltammetry (CV). Following, dopamine was finally released from the SC16SH/DA assembly upon treatment with Brij® S20 and the free dopamine was monitored by CV. Overall, our hybrid nanoassemblies turned out to be able to release dopamine, upon combined action of redox and digestion agents in medium emulating biological environment.
    Thematic Areas: Spectroscopy Química Physics, atomic, molecular & chemical Physical and theoretical chemistry Medicina ii Materials chemistry Materiais Interdisciplinar Farmacia Engenharias iii Engenharias ii Electronic, optical and magnetic materials Condensed matter physics Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Chemistry, physical Biotecnología Atomic and molecular physics, and optics Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alex.fragoso@urv.cat
    Author identifier: 0000-0003-4839-6094
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0167732221016044
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Molecular Liquids. 336 116880-
    APA: Trapani, Mariachiara; Scala, Angela; Mineo, Placido G; Pistone, Alessandro; Diaz-Moscoso, Alejandro; Fragoso, Alex; Scolaro, Luigi Monsu; Mazzaglia, A (2021). Thiolated amphiphilic β-cyclodextrin-decorated gold colloids: Synthesis, supramolecular nanoassemblies and controlled release of dopamine. Journal Of Molecular Liquids, 336(), 116880-. DOI: 10.1016/j.molliq.2021.116880
    Article's DOI: 10.1016/j.molliq.2021.116880
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Atomic and Molecular Physics, and Optics,Chemistry, Physical,Condensed Matter Physics,Electronic, Optical and Magnetic Materials,Materials Chemistry,Physical and Theoretical Chemistry,Physics, Atomic, Molecular & Chemical,Spectroscopy
    Nanovesicles
    Hybrid assemblies
    Gold colloids
    Dopamine
    Cyclic voltammetry
    Blood-brain-barrier
    Amphiphilic cyclodextrins
    vesicles
    polydisperse polymers
    perspectives
    particles
    nanovesicles
    nanostructures
    nanoparticles
    hybrid assemblies
    gold colloids
    dopamine
    delivery
    cyclic voltammetry
    complexes
    blends
    Spectroscopy
    Química
    Physics, atomic, molecular & chemical
    Physical and theoretical chemistry
    Medicina ii
    Materials chemistry
    Materiais
    Interdisciplinar
    Farmacia
    Engenharias iii
    Engenharias ii
    Electronic, optical and magnetic materials
    Condensed matter physics
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Chemistry, physical
    Biotecnología
    Atomic and molecular physics, and optics
    Astronomia / física
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