Articles producció científica> Bioquímica i Biotecnologia

Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study

  • Identification data

    Identifier: imarina:9230374
    Authors:
    Muralidharan, JananeeMoreno-Indias, IsabelBullo, MonicaVioque Lopez, JesusCorella, DoloresCastaner, OlgaVidal, JosepAtzeni, AlessandroCarlos Fernandez-Garcia, JoseTorres-Collado, LauraFernandez-Carrion, RebecaFito, MonsterratOlbeyra, RominaMaria Gomez-Perez, AnaGalie, SerenaRosa Bernal-Lopez, MariaAngel Martinez-Gonzalez, MiguelSalas-Salvado, JordiJose Tinahones, Francisco
    Abstract:
    Background: The Mediterranean diet is a well-recognized healthy diet that has shown to induce positive changes in gut microbiota. Lifestyle changes such as diet along with physical activity could aid in weight loss and improve cardiovascular risk factors.Objectives: To investigate the effect of an intensive lifestyle weight loss intervention on gut microbiota.Methods: This is a substudy of the PREDIMED-Plus (Prevention con Dieta Mediterrdnea-Plus), a randomized controlled trial conducted in overweight/obese men and women (aged 55-75 y) with metabolic syndrome. The intervention group (IG) underwent an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet) and physical activity promotion. and the control group ((Xi) underwent a non-energy-restricted MedDiet for 1 y. Anthropometric, biochemical, and gut microbial 16S rRNA sequencing data were analyzed at baseline (n = 362) and 1-y follow-up (n = 343).Results: IG participants had a weight loss of 4.2 (IQR, -6.8, -2.5) kg compared with 0.2 (IQR, -2.1. 1.4) kg in the CG (P < 0.001). Reductions in BMI, fasting glucose, glycated hemoglobin, and triglycerides and an increase in HDL cholesterol were greater in IG than inCG participants (P < 0.05). We observed a decrease in Butyricicoccus, Haentophilus. Ruminiclostridium 5, and Eubacterium hall in the IG compared with the CG. Many genera shifted in the same direction within both intervention groups, indicating an overall effect of the MedDiet. Decreases in Themophilus. Coprococcus 3, and few other genera were associated with a decrease in adiposity parameters in both intervention groups. Changes in Lachnospiraceae NK4A136 were positively associated with changes in MedDiet adherence.Conclusions: Weight loss induced by an energy-restr
  • Others:

    Author, as appears in the article.: Muralidharan, Jananee; Moreno-Indias, Isabel; Bullo, Monica; Vioque Lopez, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Atzeni, Alessandro; Carlos Fernandez-Garcia, Jose; Torres-Collado, Laura; Fernandez-Carrion, Rebeca; Fito, Monsterrat; Olbeyra, Romina; Maria Gomez-Perez, Ana; Galie, Serena; Rosa Bernal-Lopez, Maria; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Jose Tinahones, Francisco
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Atzeni, Alessandro / Bulló Bonet, Mònica / Galiè, Serena / Martínez Rodríguez, María Ángeles / Muralidharan, Jananee / Salas Salvadó, Jorge
    Keywords: Weight loss Rna, ribosomal, 16s Rna, bacterial Rna 16s Randomized controlled trial Phylogeny Overweight Obesity Middle aged Microbiology Metabolic syndrome x Metabolic syndrome Men Mediterranean diet Male Lifestyle Life style Intestine flora Humans Human Gut microbiota Genetics Gastrointestinal microbiome Female Feces Exercise Energy restriction Energy intake Diet, mediterranean Controlled study Classification Caloric restriction Caloric intake Bacterium Bacterial rna Bacteria Aged
    Abstract: Background: The Mediterranean diet is a well-recognized healthy diet that has shown to induce positive changes in gut microbiota. Lifestyle changes such as diet along with physical activity could aid in weight loss and improve cardiovascular risk factors.Objectives: To investigate the effect of an intensive lifestyle weight loss intervention on gut microbiota.Methods: This is a substudy of the PREDIMED-Plus (Prevention con Dieta Mediterrdnea-Plus), a randomized controlled trial conducted in overweight/obese men and women (aged 55-75 y) with metabolic syndrome. The intervention group (IG) underwent an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet) and physical activity promotion. and the control group ((Xi) underwent a non-energy-restricted MedDiet for 1 y. Anthropometric, biochemical, and gut microbial 16S rRNA sequencing data were analyzed at baseline (n = 362) and 1-y follow-up (n = 343).Results: IG participants had a weight loss of 4.2 (IQR, -6.8, -2.5) kg compared with 0.2 (IQR, -2.1. 1.4) kg in the CG (P < 0.001). Reductions in BMI, fasting glucose, glycated hemoglobin, and triglycerides and an increase in HDL cholesterol were greater in IG than inCG participants (P < 0.05). We observed a decrease in Butyricicoccus, Haentophilus. Ruminiclostridium 5, and Eubacterium hall in the IG compared with the CG. Many genera shifted in the same direction within both intervention groups, indicating an overall effect of the MedDiet. Decreases in Themophilus. Coprococcus 3, and few other genera were associated with a decrease in adiposity parameters in both intervention groups. Changes in Lachnospiraceae NK4A136 were positively associated with changes in MedDiet adherence.Conclusions: Weight loss induced by an energy-restricted MedDiet and physical activity induce changes in gut microbiota. The role of MedDiet-induced changes on the host might be via short-chain fatty acid producing bacteria, whereas with energy restriction, these changes might be modulated with other mechanisms, which need to be explored in future studies.
    Thematic Areas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alessandro.atzeni@urv.cat mangeles.martinez@urv.cat alessandro.atzeni@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-1804-8606 0000-0001-8595-3772 0000-0002-1804-8606 0000-0002-0218-7046 0000-0003-2700-7459
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://academic.oup.com/ajcn/article/114/3/1148/6280095?login=false
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: American Journal Of Clinical Nutrition. 114 (3): 1148-1158
    APA: Muralidharan, Jananee; Moreno-Indias, Isabel; Bullo, Monica; Vioque Lopez, Jesus; Corella, Dolores; Castaner, Olga; Vidal, Josep; Atzeni, Alessandro; (2021). Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study. American Journal Of Clinical Nutrition, 114(3), 1148-1158. DOI: 10.1093/ajcn/nqab150
    Article's DOI: 10.1093/ajcn/nqab150
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Weight loss
    Rna, ribosomal, 16s
    Rna, bacterial
    Rna 16s
    Randomized controlled trial
    Phylogeny
    Overweight
    Obesity
    Middle aged
    Microbiology
    Metabolic syndrome x
    Metabolic syndrome
    Men
    Mediterranean diet
    Male
    Lifestyle
    Life style
    Intestine flora
    Humans
    Human
    Gut microbiota
    Genetics
    Gastrointestinal microbiome
    Female
    Feces
    Exercise
    Energy restriction
    Energy intake
    Diet, mediterranean
    Controlled study
    Classification
    Caloric restriction
    Caloric intake
    Bacterium
    Bacterial rna
    Bacteria
    Aged
    Serviço social
    Saúde coletiva
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina iii
    Medicina ii
    Medicina i
    General medicine
    Enfermagem
    Educação física
    Ciências biológicas ii
    Ciência de alimentos
    Biotecnología
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