Author, as appears in the article.: Collins DR; Urbach JM; Racenet ZJ; Arshad U; Power KA; Newman RM; Mylvaganam GH; Ly NL; Lian X; Rull A; Rassadkina Y; Yanez AG; Peluso MJ; Deeks SG; Vidal F; Lichterfeld M; Yu XG; Gaiha GD; Allen TM; Walker BD
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: RULL AIXA, ANNA / Vidal Marsal, Francisco
Keywords: Human immunology Hiv control Cd8(+) t-cells Cd8 t cell dysfunction + sequence alignment responses replication pd-1 infection expression exhaustion ex-vivo activation
Abstract: Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells but is not always permanent. To address mechanisms of durable and aborted control of viremia, we evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes. Despite sustained recognition of autologous virus, HIV-specific proliferative and cytolytic T cell effector functions became selectively and intrinsically impaired prior to aborted control. Longitudinal transcriptomic profiling of functionally impaired HIV-specific CD8+ T cells revealed altered expression of genes related to activation, cytokine-mediated signaling, and cell cycle regulation, including increased expression of the antiproliferative transcription factor KLF2 but not of genes associated with canonical exhaustion. Lymphoid HIV-specific CD8+ T cells also exhibited poor functionality during aborted control relative to durable control. Our results identify selective functional impairment of HIV-specific CD8+ T cells as prognostic of impending aborted HIV control, with implications for clinical monitoring and immunotherapeutic strategies.
Thematic Areas: Medicina ii Medicina i Infectious diseases Immunology and allergy Immunology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: francesc.vidal@urv.cat
Author identifier: 0000-0002-6692-6186
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Immunity. 54 (10): 2372-2384.e7
APA: Collins DR; Urbach JM; Racenet ZJ; Arshad U; Power KA; Newman RM; Mylvaganam GH; Ly NL; Lian X; Rull A; Rassadkina Y; Yanez AG; Peluso MJ; Deeks SG; V (2021). Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity, 54(10), 2372-2384.e7. DOI: 10.1016/j.immuni.2021.08.007
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV