Articles producció científica> Medicina i Cirurgia

Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

  • Identification data

    Identifier: imarina:9230387
    Authors:
    Collins DRUrbach JMRacenet ZJArshad UPower KANewman RMMylvaganam GHLy NLLian XRull ARassadkina YYanez AGPeluso MJDeeks SGVidal FLichterfeld MYu XGGaiha GDAllen TMWalker BD
    Abstract:
    Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells but is not always permanent. To address mechanisms of durable and aborted control of viremia, we evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes. Despite sustained recognition of autologous virus, HIV-specific proliferative and cytolytic T cell effector functions became selectively and intrinsically impaired prior to aborted control. Longitudinal transcriptomic profiling of functionally impaired HIV-specific CD8+ T cells revealed altered expression of genes related to activation, cytokine-mediated signaling, and cell cycle regulation, including increased expression of the antiproliferative transcription factor KLF2 but not of genes associated with canonical exhaustion. Lymphoid HIV-specific CD8+ T cells also exhibited poor functionality during aborted control relative to durable control. Our results identify selective functional impairment of HIV-specific CD8+ T cells as prognostic of impending aborted HIV control, with implications for clinical monitoring and immunotherapeutic strategies.
  • Others:

    Author, as appears in the article.: Collins DR; Urbach JM; Racenet ZJ; Arshad U; Power KA; Newman RM; Mylvaganam GH; Ly NL; Lian X; Rull A; Rassadkina Y; Yanez AG; Peluso MJ; Deeks SG; Vidal F; Lichterfeld M; Yu XG; Gaiha GD; Allen TM; Walker BD
    Department: Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: RULL AIXA, ANNA / Vidal Marsal, Francisco
    Keywords: Human immunology Hiv control Cd8(+) t-cells Cd8 t cell dysfunction + sequence alignment responses replication pd-1 infection expression exhaustion ex-vivo activation
    Abstract: Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells but is not always permanent. To address mechanisms of durable and aborted control of viremia, we evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes. Despite sustained recognition of autologous virus, HIV-specific proliferative and cytolytic T cell effector functions became selectively and intrinsically impaired prior to aborted control. Longitudinal transcriptomic profiling of functionally impaired HIV-specific CD8+ T cells revealed altered expression of genes related to activation, cytokine-mediated signaling, and cell cycle regulation, including increased expression of the antiproliferative transcription factor KLF2 but not of genes associated with canonical exhaustion. Lymphoid HIV-specific CD8+ T cells also exhibited poor functionality during aborted control relative to durable control. Our results identify selective functional impairment of HIV-specific CD8+ T cells as prognostic of impending aborted HIV control, with implications for clinical monitoring and immunotherapeutic strategies.
    Thematic Areas: Medicina ii Medicina i Infectious diseases Immunology and allergy Immunology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: francesc.vidal@urv.cat
    Author identifier: 0000-0002-6692-6186
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.cell.com/immunity/fulltext/S1074-7613(21)00337-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS107476132100337X%3Fshowall%3Dtrue#%20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Immunity. 54 (10): 2372-2384.e7
    APA: Collins DR; Urbach JM; Racenet ZJ; Arshad U; Power KA; Newman RM; Mylvaganam GH; Ly NL; Lian X; Rull A; Rassadkina Y; Yanez AG; Peluso MJ; Deeks SG; V (2021). Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity, 54(10), 2372-2384.e7. DOI: 10.1016/j.immuni.2021.08.007
    Article's DOI: 10.1016/j.immuni.2021.08.007
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Immunology,Immunology and Allergy,Infectious Diseases
    Human immunology
    Hiv control
    Cd8(+) t-cells
    Cd8 t cell dysfunction +
    sequence alignment
    responses
    replication
    pd-1
    infection
    expression
    exhaustion
    ex-vivo
    activation
    Medicina ii
    Medicina i
    Infectious diseases
    Immunology and allergy
    Immunology
    General medicine
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
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