Articles producció científica> Ciències Mèdiques Bàsiques

Effects of a fish oil rich in docosahexaenoic acid on cardiometabolic risk factors and oxidative stress in healthy rats

  • Identification data

    Identifier: imarina:9230391
    Handle: http://hdl.handle.net/20.500.11797/imarina9230391
  • Authors:

    Miralles-Pérez B
    Méndez L
    Nogués MR
    Sánchez-Martos V
    Fortuño-Mar À
    Ramos-Romero S
    Hereu M
    Medina I
    Romeu M
  • Others:

    Author, as appears in the article.: Miralles-Pérez B; Méndez L; Nogués MR; Sánchez-Martos V; Fortuño-Mar À; Ramos-Romero S; Hereu M; Medina I; Romeu M
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Sánchez Martos, Vanessa
    Keywords: Soybean oil Protein carbonylation Polyunsaturated fatty-acids Lipid peroxidation Inflammation Glucose Eicosapentaenoic acid Coconut oil Cholesterol supplementation soybean oil protein carbonylation polyphenols plasma omega-3 pufas lipid peroxidation inflammation glutathione glucose eicosapentaenoic acid diet coconut oil cholesterol cardiovascular-disease
    Abstract: Omega-3 polyunsaturated fatty acids are associated with a lower risk of cardiometabolic diseases. However, docosahexaenoic acid (DHA) is easily oxidized, leading to cellular damage. The present study examined the effects of an increased concentration of DHA in fish oil (80% of total fatty acids) on cardiometabolic risk factors and oxidative stress compared to coconut oil, soybean oil, and fish oil containing eicosapentaenoic acid (EPA) and DHA in a balanced ratio. Forty healthy male Sprague–Dawley rats were supplemented with corresponding oil for 10 weeks. Supplementation with the fish oil containing 80% DHA decreased plasma fat, plasma total cholesterol and muscle fat compared to the coconut oil and the soybean oil. Increasing concentrations of DHA induced incorporation of DHA and EPA in cell membranes and tissues along with a decrease in ω-6 arachidonic acid. The increase in DHA promoted lipid peroxidation, protein carbonylation and antioxidant response. Taken together, the increased concentration of DHA in fish oil reduced fat accumulation compared to the coconut oil and the soybean oil. This benefit was accompanied by high lipid peroxidation and subsequent protein carbonylation in plasma and in liver. In our healthy framework, the slightly higher carbonylation found after receiving fish oil containing 80% DHA might be a protecting mechanism, which fit with the general improvement of antioxidant defense observed in those rats.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: bernat.miralles@urv.cat vanessa.sanchez@urv.cat mariarosa.nogues@urv.cat marta.romeu@urv.cat vanessa.sanchez@urv.cat bernat.miralles@urv.cat
    Author identifier: 0000-0003-1294-7069 0000-0003-4626-5672 0000-0002-2131-1858 0000-0003-1294-7069
    Record's date: 2023-02-23
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1660-3397/19/10/555
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Marine Drugs. 19 (10):
    APA: Miralles-Pérez B; Méndez L; Nogués MR; Sánchez-Martos V; Fortuño-Mar À; Ramos-Romero S; Hereu M; Medina I; Romeu M (2021). Effects of a fish oil rich in docosahexaenoic acid on cardiometabolic risk factors and oxidative stress in healthy rats. Marine Drugs, 19(10), -. DOI: 10.3390/md19100555
    Article's DOI: 10.3390/md19100555
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Chemistry, Medicinal,Drug Discovery,Pharmaceutical Science,Pharmacology & Pharmacy,Pharmacology, Toxicology and Pharmaceutics (Miscellaneous)
    Soybean oil
    Protein carbonylation
    Polyunsaturated fatty-acids
    Lipid peroxidation
    Inflammation
    Glucose
    Eicosapentaenoic acid
    Coconut oil
    Cholesterol
    supplementation
    soybean oil
    protein carbonylation
    polyphenols
    plasma
    omega-3 pufas
    lipid peroxidation
    inflammation
    glutathione
    glucose
    eicosapentaenoic acid
    diet
    coconut oil
    cholesterol
    cardiovascular-disease
    Zootecnia / recursos pesqueiros
    Química
    Pharmacology, toxicology and pharmaceutics (miscellaneous)
    Pharmacology & pharmacy
    Pharmaceutical science
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    Farmacia
    Engenharias iii
    Engenharias ii
    Educação física
    Drug discovery
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Biotecnología
    Biodiversidade
    Astronomia / física
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