Articles producció científica> Ciències Mèdiques Bàsiques

Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial

  • Identification data

    Identifier: imarina:9230612
    Authors:
    Laguna, Juan C.Alegret, MartaCofan, MontserratSanchez-Tainta, AnaDiaz-Lopez, AndresMartinez-Gonzalez, Miguel A.V. Sorli, JoseSalas-Salvado, JordiFito, MontserratAlonso-Gomez, Angel M.Serra-Majem, LluisLaperra, JoseFiol, MiquelGomez-Gracia, EnriquePinto, XavierMunoz, Miguel A.Castaner, OlgaRamirez-Sabio, Judith B.Portu, Jose J.Estruch, RamonRos, Emilio
    Abstract:
    Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses
  • Others:

    Author, as appears in the article.: Laguna, Juan C.; Alegret, Marta; Cofan, Montserrat; Sanchez-Tainta, Ana; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A.; V. Sorli, Jose; Salas-Salvado, Jordi; Fito, Montserrat; Alonso-Gomez, Angel M.; Serra-Majem, Lluis; Laperra, Jose; Fiol, Miquel; Gomez-Gracia, Enrique; Pinto, Xavier; Munoz, Miguel A.; Castaner, Olga; Ramirez-Sabio, Judith B.; Portu, Jose J.; Estruch, Ramon; Ros, Emilio;
    Department: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    URV's Author/s: Díaz López, Andres / Salas Salvadó, Jorge
    Keywords: Sweetened beverages Sugar-sweetened beverage Sugar intake Risk Randomized controlled trial Prospective study Prevalence Population Physical-activity questionnaire Patient participation Pancreatic-cancer Observational study Obesity Multicenter study Male Major clinical study Liquid form Human High risk population Groups by age Glycemic index Glucose intake Glucose Fruit juice Fructose intake Fructose Follow up Female Dietary sugar Diabetes-mellitus Diabetes mellitus Controlled study Consumption Cohort analysis Cardiovascular risk Cardiovascular disease Cancer risk Cancer mortality Cancer incidence Body-mass index Article All cause mortality Aged
    Abstract: Objective: To examine associations between intake of simple sugars and cancer incidence, cancer mor-tality, and total mortality in a prospective cohort study based on the PREDIMED trial conducted from 2003 to 2010. Methods: Participants were older individuals at high cardiovascular risk. Exposures were total sugar, glucose and fructose from solid or liquid sources, and fructose from fruit and 100% fruit juice. Cancer incidence was the primary outcome; cancer mortality and all-cause mortality were secondary outcomes. Multivariable-adjusted, time-dependent Cox proportional hazard models were used. Results: Of 7447 individuals enrolled, 7056 (94.7%) were included (57.6% women, aged 67.0 +/- 6.2 years). 534 incident cancers with 152 cancer deaths and 409 all-cause deaths were recorded after a median follow-up of 6 years. Intake of simple sugars in solid form was unrelated to outcomes. Higher cancer incidence was found per 5 g/day increase in intake of liquid sugars, with multivariable-adjusted HR of 1.08 (95% CI, 1.03-1.13) for total liquid sugar, 1.19 (95% CI, 1.07-1.31) for liquid glucose, 1.14 (95% CI, 1.05-1.23) for liquid fructose, and 1.39 (95% CI, 1.10-1.74) for fructose from fruit juice. Cancer and all-cause mortality increased to a similar extent with intake of all sugars in liquid form. In categorical models, cancer risk was dose-related for all liquid sugars. Conclusions: Simple sugar intake in drinks and fruit juice was associated with an increased risk of overall cancer incidence and mortality and all-cause mortality. This suggests that sugary beverages are a modifiable risk factor for cancer and all-cause mortality. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: andres.diaz@urv.cat jordi.salas@urv.cat
    Author identifier: 0000-0002-7500-5629 0000-0003-2700-7459
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Nutrition. 40 (10): 5269-5277
    APA: Laguna, Juan C.; Alegret, Marta; Cofan, Montserrat; Sanchez-Tainta, Ana; Diaz-Lopez, Andres; Martinez-Gonzalez, Miguel A.; V. Sorli, Jose; Salas-Salva (2021). Simple sugar intake and cancer incidence, cancer mortality and all- cause mortality: A cohort study from the PREDIMED trial. Clinical Nutrition, 40(10), 5269-5277. DOI: 10.1016/j.clnu.2021.07.031
    Article's DOI: 10.1016/j.clnu.2021.07.031
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Critical Care and Intensive Care Medicine,Nutrition & Dietetics,Nutrition and Dietetics
    Sweetened beverages
    Sugar-sweetened beverage
    Sugar intake
    Risk
    Randomized controlled trial
    Prospective study
    Prevalence
    Population
    Physical-activity questionnaire
    Patient participation
    Pancreatic-cancer
    Observational study
    Obesity
    Multicenter study
    Male
    Major clinical study
    Liquid form
    Human
    High risk population
    Groups by age
    Glycemic index
    Glucose intake
    Glucose
    Fruit juice
    Fructose intake
    Fructose
    Follow up
    Female
    Dietary sugar
    Diabetes-mellitus
    Diabetes mellitus
    Controlled study
    Consumption
    Cohort analysis
    Cardiovascular risk
    Cardiovascular disease
    Cancer risk
    Cancer mortality
    Cancer incidence
    Body-mass index
    Article
    All cause mortality
    Aged
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Critical care and intensive care medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Biotecnología
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