Articles producció científicaMedicina i Cirurgia

Long-term exposure to PM10 above WHO guidelines exacerbates COVID-19 severity and mortality

  • Identification data

    Identifier:  imarina:9230629
    Authors:  Marquès, M; Correig, E; Ibarretxe, D; Anoro, E; Arroyo, JA; Jericó, C; Borrallo, RM; la Miret, M; Näf, S; Pardo, A; Perea, V; Pérez-Bernalte, R; Ramírez-Montesinos, R; Royuela, M; Soler, C; Urquizu-Padilla, M; Zamora, A; Pedro-Botet, J; Masana, L; Domingo, JL
    Abstract:
    Background: Age, sex, race and comorbidities are insufficient to explain why some individuals remain asymptomatic after SARS-CoV-2 infection, while others die. In this sense, the increased risk caused by the long-term exposure to air pollution is being investigated to understand the high heterogeneity of the COVID-19 infection course. Objectives: We aimed to assess the underlying effect of long-term exposure to NO2 and PM10 on the severity and mortality of COVID-19. Methods: A retrospective observational study was conducted with 2112 patients suffering COVID-19 infection. We built two sets of multivariate predictive models to assess the relationship between the long-term exposure to NO2 and PM10 and COVID-19 outcome. First, the probability of either death or severe COVID-19 outcome was predicted as a function of all the clinical variables together with the pollutants exposure by means of two regularized logistic regressions. Subsequently, two regularized linear regressions were constructed to predict the percentage of dead or severe patients. Finally, odds ratios and effects estimates were calculated. Results: We found that the long-term exposure to PM10 is a more important variable than some already stated comorbidities (i.e.: COPD/Asthma, diabetes, obesity) in the prediction of COVID-19 severity and mortality. PM10 showed the highest effects estimates (1.65, 95% CI 1.32–2.06) on COVID-19 severity. For mortality, the highest effect estimates corresponded to age (3.59, 95% CI 2.94–4.40), followed by PM10 (2.37, 95% CI 1.71–3.32). Finally, an increase of 1 µg/m3 in PM10 concentration causes an increase of 3.06% (95% CI 1.11%-4.25%) of patients suffering COVID-19 as a severe disease and an increase of 2.68% (95% CI 0.53%-5.58%) of deaths. Discussion: These results demonstrate that long-term PM10 burdens above WHO guidelines exacerbate COVID-19 health outcomes. Hence, WHO guidelines, the air quality standard established by the Directive 2008/50/EU, and that of the US-EPA should be updated accordingly to protect human health.
  • Others:

    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0160412021005559?via%3Dihub
    APA: Marquès, M; Correig, E; Ibarretxe, D; Anoro, E; Arroyo, JA; Jericó, C; Borrallo, RM; la Miret, M; Näf, S; Pardo, A; Perea, V; Pérez-Bernalte, R; Ramír (2022). Long-term exposure to PM10 above WHO guidelines exacerbates COVID-19 severity and mortality. ENVIRONMENT INTERNATIONAL, 158(), 106930-. DOI: 10.1016/j.envint.2021.106930
    Paper original source: ENVIRONMENT INTERNATIONAL. 158 106930-
    Article's DOI: 10.1016/j.envint.2021.106930
    Journal publication year: 2022-01-01
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-05-02
    URV's Author/s: Correig Fraga, Eudald / Domingo Roig, José Luis / Ibarretxe Gerediaga, Daiana / Marquès Bueno, Montserrat / Masana Marín, Luis
    Department: Medicina i Cirurgia, Ciències Mèdiques Bàsiques
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Marquès, M; Correig, E; Ibarretxe, D; Anoro, E; Arroyo, JA; Jericó, C; Borrallo, RM; la Miret, M; Näf, S; Pardo, A; Perea, V; Pérez-Bernalte, R; Ramírez-Montesinos, R; Royuela, M; Soler, C; Urquizu-Padilla, M; Zamora, A; Pedro-Botet, J; Masana, L; Domingo, JL
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Zootecnia / recursos pesqueiros, Saúde coletiva, Química, Medicina iii, Medicina ii, Medicina i, Interdisciplinar, Geociências, General medicine, General environmental science, Farmacia, Environmental sciences, Environmental science (miscellaneous), Environmental science (all), Engenharias iv, Engenharias ii, Engenharias i, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Ciências ambientais, Ciências agrárias i, Biotecnología, Biodiversidade, Astronomia / física, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: daiana.ibarretxe@urv.cat, daiana.ibarretxe@urv.cat, montserrat.marques@urv.cat, montserrat.marques@urv.cat, eudald.correig@urv.cat, joseluis.domingo@urv.cat, joseluis.domingo@urv.cat, luis.masana@urv.cat, luis.masana@urv.cat
  • Keywords:

    Pm10
    Good health and well-being
    Covid-19 severity
    Covid-19 mortality
    Covid-19
    Air-pollution
    risks
    population
    associations
    Environmental Science (Miscellaneous)
    Environmental Sciences
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental science (all)
    Engenharias iv
    Engenharias ii
    Engenharias i
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas
    ciências contábeis e turismo
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