Author, as appears in the article.: Avila-Roman, Javier; Garcia-Gil, Sara; Rodriguez-Luna, Azahara; Motilva, Virginia; Talero, Elena;
Department: Bioquímica i Biotecnologia
URV's Author/s: Ávila Román, Francisco Javier
Keywords: Oxidative stress Non-hodgkin-lymphoma Nf-kappa-b Modulating oxidative stress Microalgae Macular pigment density Inflammation High-fat-diet Fucoxanthin induces apoptosis Depressive-like behavior Cell-cycle arrest Carotenoids Cancer Breast-cancer risk Acute lung injury
Abstract: Acute inflammation is a key component of the immune system's response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as alpha- and beta-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, alpha- and beta-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.</p>
Thematic Areas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: franciscojavier.avila@urv.cat
Author identifier: 0000-0001-9766-8178
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1660-3397/19/10/531
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Marine Drugs. 19 (10):
APA: Avila-Roman, Javier; Garcia-Gil, Sara; Rodriguez-Luna, Azahara; Motilva, Virginia; Talero, Elena; (2021). Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids. Marine Drugs, 19(10), -. DOI: 10.3390/md19100531
Article's DOI: 10.3390/md19100531
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV