Repositori URV

Author, as appears in the article.: Claria, Joan; Curto, Anna; Moreau, Richard; Colsch, Benoit; Lopez-Vicario, Cristina; Lozano, Juan Jose; Aguilar, Ferran; Castelli, Florence A; Fenaille, Francois; Junot, Christophe; Zhang, Ingrid; Vinaixa, Maria; Yanes, Oscar; Caraceni, Paolo; Trebicka, Jonel; Fernandez, Javier; Angeli, Paolo; Jalan, Rajiv; Arroyo, Vicente

Department: Enginyeria Electrònica, Elèctrica i Automàtica

URV's Author/s: Vinaixa Crevillent, Maria / Yanes Torrado, Óscar

Keywords: Systemic inflammation Survival Sphingosine 1 phosphate Sphingomyelin Sphingolipid Phosphatidylcholine sterol acyltransferase Phosphatidylcholine Pathophysiology Palmitoleic acid Organ failures Or-gan failures Omega 3 fatty acid Monounsaturated fatty acid Middle aged Male Major clinical study Lysophosphatidylcholine Liver dysfunction Liquid chromatography-mass spectrometry Lipids Lipidomics Lipidome Lipid metabolism Lipid homeostasis Lipid fingerprinting Lipid blood level Immune response Icosapentaenoic acid Human serum albumin Human Hepatitis Follow up Female Docosahexaenoic acid Disease severity Disease course Disease association Disease Decompensated liver cirrhosis Decompensated cirrhosis Cytokine Controlled study Cohort analysis Cholesterol ester Ceramide C reactive protein Blood sampling Article Adult Acute on chronic liver failure Acute disease

Abstract: Background & Aims: Acute decompensation (AD) of cirrhosis is a heterogeneous clinical entity associated with moderate mortality. In some patients, this condition develops quickly into the more deadly acute-on-chronic liver failure (ACLF), in which other organs such as the kidneys or brain fail. The aim of this study was to characterize the blood lipidome in a large series of patients with cirrhosis and identify specific signatures associated with AD and ACLF development. Methods: Serum untargeted lipidomics was performed in 561 patients with AD (518 without and 43 with ACLF) (discovery cohort) and in 265 patients with AD (128 without and 137 with ACLF) in whom serum samples were available to perform repeated measurements during the 28-day follow-up (validation cohort). Analyses were also performed in 78 patients with AD included in a therapeutic albumin trial (43 patients with compensated cirrhosis and 29 healthy individuals). Results: The circulating lipid landscape associated with cirrhosis was characterized by a generalized suppression, which was more manifest during AD and in non-surviving patients. By computing discriminating accuracy and the variable importance projection score for each of the 223 annotated lipids, we identified a sphingomyelin fingerprint specific for AD of cirrhosis and a distinct cholesteryl ester and lysophosphatidylcholine finger-print for ACLF. Liver dysfunction and infections were the prin-cipal net contributors to these fingerprints, which were dynamic and interchangeable between patients with AD whose condition worsened to ACLF and those who improved. Notably, blood lysophosphatidylcholine levels increased in these patients after albumin therapy. Conclusions: Our findings provide insights into the lipid land-scape associated with decompensation of cirrhosis and ACLF progression and identify unique non-invasive diagnostic bio-markers of advanced cirrhosis. Lay summary: Analysis of lipids in blood from patients with advanced cirrhosis reveals a general suppression of their levels in the circulation of these patients. A specific group of lipids known as sphingomyelins are useful to distinguish between patients with compensated and decompensated cirrhosis. Another group of lipids designated cholesteryl esters further distinguishes patients with decompensated cirrhosis who are at risk of developing organ failures. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Thematic Areas: Química Medicina ii Medicina i Interdisciplinar Hepatology General medicine Gastroenterology & hepatology Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: maria.vinaixa@urv.cat oscar.yanes@urv.cat maria.vinaixa@urv.cat

Author identifier: 0000-0001-9804-0171 0000-0003-3695-7157 0000-0001-9804-0171

Record's date: 2024-10-12

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.journal-of-hepatology.eu/article/S0168-8278(21)01895-X/fulltext

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Hepatology. 75 (5): 1116-1127

APA: Claria, Joan; Curto, Anna; Moreau, Richard; Colsch, Benoit; Lopez-Vicario, Cristina; Lozano, Juan Jose; Aguilar, Ferran; Castelli, Florence A; Fenaill (2021). Untargeted lipidomics uncovers lipid signatures that distinguish severe from moderate forms of acutely decompensated cirrhosis. Journal Of Hepatology, 75(5), 1116-1127. DOI: 10.1016/j.jhep.2021.06.043

Article's DOI: 10.1016/j.jhep.2021.06.043

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications