Author, as appears in the article.: Cardenas-Fuentes, Gabriela; Lassale, Camille; Martinez-Gonzalez, Miguel Angel; Grau, Maria; Salas-Salvado, Jordi; Corella, Dolores; Serra-Majem, Lluis; Warnberg, Julia; Konieczna, Jadwiga; Estruch, Ramon; Pinto, Xavier; Alfredo Martinez, J.; Vazquez, Clotilde; Vidal, Josep; Tur, Josep A.; Diaz-Lopez, Andres; Lancova, Hana; Fito, Montserrat; Schroder, Helmut;
Department: Bioquímica i Biotecnologia
URV's Author/s: Díaz López, Andres / Salas Salvadó, Jorge
Keywords: Waist circumference Visceral fat Older-adults Mediterranean diet Mediation analysis Markers Interventions Inflammation Exercise Disease C-reactive protein Body mass index Biomarkers Adherence waist circumference visceral fat older-adults mediterranean diet mediation analysis markers interventions inflammation exercise disease biomarkers adherence
Abstract: Background: Mechanisms underlying the associations of high levels of physical activity (PA) and adherence to the Mediterranean diet (MedDiet) with a better inflammatory profile remain unclear. Our objective was to assess the mediating role of changes in body mass index (BMI) and waist circumference (WC), as markers of body fat in the association of changes in PA and adherence to the MedDiet, with changes in the inflammatory profile.Method: This study included 489 adults, aged 55-75 years, from the PREDIMED-Plus multicenter lifestyle intervention trial. An inflammatory score was calculated, based on 8 blood biomarkers: high-sensitivity C-reactive protein, interleukin 6, interleukin 8, interleukin 18, monocyte chemo-attractant protein-1, C-peptide, leptin, and regulated on activation, normal T-cell-expressed and secreted chemokine. Biomarkers, levels of PA, score of MedDiet adherence, BMI, and WC were measured at baseline and at 1-year follow-up. Linear regression models were fitted according to the Baron and Kenny framework for mediation analysis.Results: Changes in BMI and WC mediated the association of both changes in PA and changes in the MedDiet adherence with the inflammatory score. Body mass index mediated 26% of the association of changes in total PA with the inflammatory profile, and 27% of the association of changes in the MedDiet, while WC mediated 13% and 12% of these associations, respectively.Conclusion: In older adults at high cardiovascular risk, increasing PA levels and adherence to a MedDiet during 1 year were associated with a lower inflammatory score, which was partly mediated by a reduction in body fat.
Thematic Areas: Sociologia i política Saúde coletiva Psychology Planejamento urbano e regional / demografia Odontología Nutrição Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Gerontology Geriatrics and gerontology Geriatrics & gerontology General medicine Educação física Ciencias sociales Ciências biológicas ii Ciências biológicas i Ciências ambientais Biotecnología Aging
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andres.diaz@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-7500-5629 0000-0003-2700-7459
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences. 76 (11): 2021-2029
APA: Cardenas-Fuentes, Gabriela; Lassale, Camille; Martinez-Gonzalez, Miguel Angel; Grau, Maria; Salas-Salvado, Jordi; Corella, Dolores; Serra-Majem, Lluis (2021). Anthropometric Variables as Mediators of the Association of Changes in Diet and Physical Activity With Inflammatory Profile. Journals Of Gerontology Series A-Biological Sciences And Medical Sciences, 76(11), 2021-2029. DOI: 10.1093/gerona/glab072
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV