Author, as appears in the article.: Sendra, Jana; Reyes, Efraim; Prieto, Liher; Fernandez, Elena; Vicario, Jose L
Department: Química Física i Inorgànica
URV's Author/s: Fernández Gutiérrez, Maria Elena
Keywords: Silicon lewis-acid ring contraction phosphoric-acid asymmetric-synthesis 1,3-dipolar cycloadditions
Abstract: Hydrazones derived from cycloalkenones undergo an enantioselective transannular formal (3 + 2) cycloaddition catalyzed by a chiral phosphoric acid. The reaction provides high yields and excellent stereocontrol in the formation of complex adducts with one or two α-tertiary amine moieties at the ring fusion, and these can be converted into very versatile stereodefined decalin- or octahydro-1H-indene-derived 1,3-diamines through simple reductive N-N cleavage.
Thematic Areas: Química Physical and theoretical chemistry Organic chemistry Medicina ii Medicina i Materiais Interdisciplinar General medicine Farmacia Ciências biológicas ii Ciências biológicas i Ciências agrárias i Chemistry, organic Biotecnología Biodiversidade Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mariaelena.fernandez@urv.cat
Author identifier: 0000-0001-9025-1791
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Organic Letters. 23 (22): 8738-8743
APA: Sendra, Jana; Reyes, Efraim; Prieto, Liher; Fernandez, Elena; Vicario, Jose L (2021). Transannular Enantioselective (3 + 2) Cycloaddition of Cycloalkenone Hydrazones under Brønsted Acid Catalysis. Organic Letters, 23(22), 8738-8743. DOI: 10.1021/acs.orglett.1c03190
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV