Author, as appears in the article.: Gomez-Martinez, Carlos; Babio, Nancy; Julvez, Jordi; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Castaner, Olga; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M.; Warnberg, Julia; Martinez, Jose A.; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; Bueno-Cavanillas, Aurora; Gaforio, Jose J.; Matia-Martin, Pilar; Daimiel, Lidia; Martin-Sanchez, Vicente; Vidal, Josep; Vazquez, Clotilde; Ros, Emilio; Dalsgaard, Soren; Sayon-Orea, Carmen; Sorli, Jose, V; de la Torre, Rafael; Abete, Itziar; Tojal-Sierra, Lucas; Baron-Lopez, Francisco J.; Fernandez-Brufal, Noelia; Konieczna, Jadwiga; Garcia-Rios, Antonio; Sacanella, Emilio; Bernal-Lopez, M. Rosa; Santos-Lozano, Jose M.; Razquin, Cristina; Alvarez-Sala, Andrea; Goday, Albert; Angeles Zulet, M.; Vaquero-Luna, Jessica; Diez-Espino, Javier; Cuenca-Royo, Aida; Fernandez-Aranda, Fernando; Bullo, Monica; Salas-Salvado, Jordi;PREDIMED-Plus Investigators
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: Working memory Validation Type 2 diabetes Trail making test Sex difference Sensitivity analysis Randomized controlled trial Prospective study Processing speed Prevalence Prediabetes Physical-activity questionnaire Physical activity Parallel design Observational study Obesity Non insulin dependent diabetes mellitus Multicenter study Mini mental state examination Middle aged Metabolic syndrome x Metaanalysis Male Major clinical study Insulin-resistance Insulin treatment Insulin resistance Insulin Impaired glucose tolerance Hypoglycemic episodes Hypertension Hypercholesterolemia Human Homeostasis model assessment Homa index Hemoglobin a1c Glycemic control Glycated (glycosylated) hemoglobin Glucose Follow up Female Executive function test Education Diabetes-mellitus Diabetes mellitus Diabetes duration Diabetes control Depression Dementia Decline Controlled study Cohort analysis Cognitive function Cognition Cardiovascular risk Cardiovascular disease Body mass Article Aged Age Adults Adult
Abstract: IntroductionType 2 diabetes has been linked to greater cognitive decline, but other glycemic parameters such as prediabetes, diabetes control and treatment, and HOMA-IR and HbA(1c) diabetes-related biomarkers have shown inconsistent results. Furthermore, there is limited research assessing these relationships in short-term studies. Thus, we aimed to examine 2-year associations between baseline diabetes/glycemic status and changes in cognitive function in older participants at high risk of cardiovascular disease.</p> MethodsWe conducted a 2-year prospective cohort study (n=6,874) within the framework of the PREDIMED-Plus study. The participants (with overweight/obesity and metabolic syndrome; mean age 64.9 years; 48.5% women) completed a battery of 8 cognitive tests, and a global cognitive function Z-score (GCF) was estimated. At baseline, participants were categorized by diabetes status (no-diabetes, prediabetes, and <5 or >= 5-year diabetes duration), and also by diabetes control. Furthermore, insulin resistance (HOMA-IR) and glycated hemoglobin (HbA(1c)) levels were measured, and antidiabetic medications were recorded. Linear and logistic regression models, adjusted by potential confounders, were fitted to assess associations between glycemic status and changes in cognitive function.</p> ResultsPrediabetes status was unrelated to cognitive decline. However, compared to participants without diabetes, those with >= 5-year diabetes duration had greater reductions in GCF (beta=-0.11 (95%CI -0.16;-0.06)], as well as in processing speed and executive function measurements. Inverse associations were observed between baseline HOMA-IR and changes in GCF [beta=-0.0094 (95%CI -0.0164;-0.0023)], but also between HbA(1c) levels and changes in GCF [beta=-0.0085 (95%CI -0.0115, -0.0055)], the Mini-Mental State Examination, and other executive function tests. Poor diabetes control was inversely associated with phonologic fluency. The use of insulin treatment was inversely related to cognitive function as measured by the GCF [beta=-0.31 (95%CI -0.44, -0.18)], and other cognitive tests.</p> ConclusionsInsulin resistance, diabetes status, longer diabetes duration, poor glycemic control, and insulin treatment were associated with worsening cognitive function changes in the short term in a population at high cardiovascular risk.</p>
Thematic Areas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nerea.becerra@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat
Author identifier: 0000-0002-4429-6507 0000-0003-3527-5277 0000-0003-2700-7459 0000-0002-0218-7046
Record's date: 2023-09-02
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fendo.2021.754347/full
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Frontiers In Endocrinology. 12
APA: Gomez-Martinez, Carlos; Babio, Nancy; Julvez, Jordi; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Castaner, Olga; Romaguera, (2021). Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study. Frontiers In Endocrinology, 12(), -. DOI: 10.3389/fendo.2021.754347
Article's DOI: 10.3389/fendo.2021.754347
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV