Articles producció científica> Bioquímica i Biotecnologia

Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study

  • Identification data

    Identifier: imarina:9232640
    Authors:
    Gomez-Martinez, CarlosBabio, NancyJulvez, JordiBecerra-Tomas, NereaMartinez-Gonzalez, Miguel ACorella, DoloresCastaner, OlgaRomaguera, DoraVioque, JesusAlonso-Gomez, Angel MWarnberg, JuliaMartinez, Jose ASerra-Majem, LuisEstruch, RamonTinahones, Francisco JLapetra, JosePinto, XavierTur, Josep ALopez-Miranda, JoseBueno-Cavanillas, AuroraGaforio, Jose JMatia-Martin, PilarDaimiel, LidiaMartin-Sanchez, VicenteVidal, JosepVazquez, ClotildeRos, EmilioDalsgaard, SorenSayon-Orea, CarmenSorli, Jose, Vde la Torre, RafaelAbete, ItziarTojal-Sierra, LucasBaron-Lopez, Francisco JFernandez-Brufal, NoeliaKonieczna, JadwigaGarcia-Rios, AntonioSacanella, EmilioBernal-Lopez, M RosaSantos-Lozano, Jose MRazquin, CristinaAlvarez-Sala, AndreaGoday, AlbertAngeles Zulet, MVaquero-Luna, JessicaDiez-Espino, JavierCuenca-Royo, AidaFernandez-Aranda, FernandoBullo, MonicaSalas-Salvado, Jordi
    Abstract:
    IntroductionType 2 diabetes has been linked to greater cognitive decline, but other glycemic parameters such as prediabetes, diabetes control and treatment, and HOMA-IR and HbA(1c) diabetes-related biomarkers have shown inconsistent results. Furthermore, there is limited research assessing these relationships in short-term studies. Thus, we aimed to examine 2-year associations between baseline diabetes/glycemic status and changes in cognitive function in older participants at high risk of cardiovascular disease.

    MethodsWe conducted a 2-year prospective cohort study (n=6,874) within the framework of the PREDIMED-Plus study. The participants (with overweight/obesity and metabolic syndrome; mean age 64.9 years; 48.5% women) completed a battery of 8 cognitive tests, and a global cognitive function Z-score (GCF) was estimated. At baseline, participants were categorized by diabetes status (no-diabetes, prediabetes, and <5 or >= 5-year diabetes duration), and also by diabetes control. Furthermore, insulin resistance (HOMA-IR) and glycated hemoglobin (HbA(1c)) levels were measured, and antidiabetic medications were recorded. Linear and logistic regression models, adjusted by potential confounders, were fitted to assess associations between glycemic status and changes in cognitive function.

    ResultsPrediabetes status was unrelated to cognitive decline. However, compared to participants without diabetes, those with >= 5-year diabetes duration had greater reductions in GCF (beta=-0.11 (95%CI -0.16;-0.06)], as well as in processing speed and executive function measurements. Inverse associations were observed between baseline HOMA-IR and changes in GCF [beta=-0.0094 (95%CI -0.0164;-0.0023)], but also between HbA(1c) levels and changes in GCF [beta=-0.0085 (95%CI -0.0115, -0.0
  • Others:

    Author, as appears in the article.: Gomez-Martinez, Carlos; Babio, Nancy; Julvez, Jordi; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A; Corella, Dolores; Castaner, Olga; Romaguera, Dora; Vioque, Jesus; Alonso-Gomez, Angel M; Warnberg, Julia; Martinez, Jose A; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Pinto, Xavier; Tur, Josep A; Lopez-Miranda, Jose; Bueno-Cavanillas, Aurora; Gaforio, Jose J; Matia-Martin, Pilar; Daimiel, Lidia; Martin-Sanchez, Vicente; Vidal, Josep; Vazquez, Clotilde; Ros, Emilio; Dalsgaard, Soren; Sayon-Orea, Carmen; Sorli, Jose, V; de la Torre, Rafael; Abete, Itziar; Tojal-Sierra, Lucas; Baron-Lopez, Francisco J; Fernandez-Brufal, Noelia; Konieczna, Jadwiga; Garcia-Rios, Antonio; Sacanella, Emilio; Bernal-Lopez, M Rosa; Santos-Lozano, Jose M; Razquin, Cristina; Alvarez-Sala, Andrea; Goday, Albert; Angeles Zulet, M; Vaquero-Luna, Jessica; Diez-Espino, Javier; Cuenca-Royo, Aida; Fernandez-Aranda, Fernando; Bullo, Monica; Salas-Salvado, Jordi
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Bulló Bonet, Mònica / Salas Salvadó, Jorge
    Keywords: Working memory Validation Type 2 diabetes Trail making test Sex difference Sensitivity analysis Randomized controlled trial Prospective study Processing speed Prevalence Prediabetes Physical-activity questionnaire Physical activity Parallel design Observational study Obesity Non insulin dependent diabetes mellitus Multicenter study Mini mental state examination Middle aged Metabolic syndrome x Metaanalysis Male Major clinical study Insulin-resistance Insulin treatment Insulin resistance Insulin Impaired glucose tolerance Hypoglycemic episodes Hypertension Hypercholesterolemia Human Homeostasis model assessment Homa index Hemoglobin a1c Glycemic control Glycated (glycosylated) hemoglobin Glucose Follow up Female Executive function test Education Diabetes-mellitus Diabetes mellitus Diabetes duration Diabetes control Depression Dementia Decline Controlled study Cohort analysis Cognitive function Cognition Cardiovascular risk Cardiovascular disease Body mass Article Aged Age Adults Adult
    Abstract: IntroductionType 2 diabetes has been linked to greater cognitive decline, but other glycemic parameters such as prediabetes, diabetes control and treatment, and HOMA-IR and HbA(1c) diabetes-related biomarkers have shown inconsistent results. Furthermore, there is limited research assessing these relationships in short-term studies. Thus, we aimed to examine 2-year associations between baseline diabetes/glycemic status and changes in cognitive function in older participants at high risk of cardiovascular disease.</p> MethodsWe conducted a 2-year prospective cohort study (n=6,874) within the framework of the PREDIMED-Plus study. The participants (with overweight/obesity and metabolic syndrome; mean age 64.9 years; 48.5% women) completed a battery of 8 cognitive tests, and a global cognitive function Z-score (GCF) was estimated. At baseline, participants were categorized by diabetes status (no-diabetes, prediabetes, and <5 or >= 5-year diabetes duration), and also by diabetes control. Furthermore, insulin resistance (HOMA-IR) and glycated hemoglobin (HbA(1c)) levels were measured, and antidiabetic medications were recorded. Linear and logistic regression models, adjusted by potential confounders, were fitted to assess associations between glycemic status and changes in cognitive function.</p> ResultsPrediabetes status was unrelated to cognitive decline. However, compared to participants without diabetes, those with >= 5-year diabetes duration had greater reductions in GCF (beta=-0.11 (95%CI -0.16;-0.06)], as well as in processing speed and executive function measurements. Inverse associations were observed between baseline HOMA-IR and changes in GCF [beta=-0.0094 (95%CI -0.0164;-0.0023)], but also between HbA(1c) levels and changes in GCF [beta=-0.0085 (95%CI -0.0115, -0.0055)], the Mini-Mental State Examination, and other executive function tests. Poor diabetes control was inversely associated with phonologic fluency. The use of insulin treatment was inversely related to cognitive function as measured by the GCF [beta=-0.31 (95%CI -0.44, -0.18)], and other cognitive tests.</p> ConclusionsInsulin resistance, diabetes status, longer diabetes duration, poor glycemic control, and insulin treatment were associated with worsening cognitive function changes in the short term in a population at high cardiovascular risk.</p>
    Thematic Areas: Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Ciências biológicas ii Ciências biológicas i
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nerea.becerra@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-4429-6507 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fendo.2021.754347/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers In Endocrinology. 12 754347-
    APA: Gomez-Martinez, Carlos; Babio, Nancy; Julvez, Jordi; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A; Corella, Dolores; Castaner, Olga; Romaguera, D (2021). Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study. Frontiers In Endocrinology, 12(), 754347-. DOI: 10.3389/fendo.2021.754347
    Article's DOI: 10.3389/fendo.2021.754347
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism
    Working memory
    Validation
    Type 2 diabetes
    Trail making test
    Sex difference
    Sensitivity analysis
    Randomized controlled trial
    Prospective study
    Processing speed
    Prevalence
    Prediabetes
    Physical-activity questionnaire
    Physical activity
    Parallel design
    Observational study
    Obesity
    Non insulin dependent diabetes mellitus
    Multicenter study
    Mini mental state examination
    Middle aged
    Metabolic syndrome x
    Metaanalysis
    Male
    Major clinical study
    Insulin-resistance
    Insulin treatment
    Insulin resistance
    Insulin
    Impaired glucose tolerance
    Hypoglycemic episodes
    Hypertension
    Hypercholesterolemia
    Human
    Homeostasis model assessment
    Homa index
    Hemoglobin a1c
    Glycemic control
    Glycated (glycosylated) hemoglobin
    Glucose
    Follow up
    Female
    Executive function test
    Education
    Diabetes-mellitus
    Diabetes mellitus
    Diabetes duration
    Diabetes control
    Depression
    Dementia
    Decline
    Controlled study
    Cohort analysis
    Cognitive function
    Cognition
    Cardiovascular risk
    Cardiovascular disease
    Body mass
    Article
    Aged
    Age
    Adults
    Adult
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Ciências biológicas ii
    Ciências biológicas i
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