Author, as appears in the article.: Cabrera, Cristian; Vicens, Paloma; Torrente, Margarita
Department: Psicologia
URV's Author/s: Cabrera Marchante, Cristian / Torrente Torné, Margarita / Vicens Calderón, Paloma
Keywords: Traumatic brain-injury Risk factors Risk factor Prevention. Lifestyle Inflammation Humans Gut microbiota Gastrointestinal microbiome Dysbiosis Dementia risk factor prevention parkinsons-disease lifestyle hearing-loss gut microbiota gastrointestinal microbiome frontotemporal dementia dysbiosis cigarette-smoking body-mass index bacterial translocation alzheimers-disease air-pollution
Abstract: :Dementia is a syndrome resulting from chronic or progressive brain disease. Around 40% of worldwide dementia can be prevented or delayed by modifying 12 risk factors: low educational attainment in early life, mid-life hypertension, mid-life obesity, hearing loss, traumatic brain injury, excessive alcohol consumption, smoking, depression, physical inactivity, social isolation, diabetes mellitus, and air pollution. There is growing evidence that gastrointestinal tract microbiota may significantly contribute to dementia pathogenesis. In particular, gut dysbiosis can trigger metabolic diseases and the progression of low-grade systemic inflammation, being involved in much of the major modifiable risk factors. In this review, we focus on studies that have evaluated the association between modifiable risk factors for dementia and the role of gut microbiota. We also suggest clinical implications for researchers in dementia-gut microbiota related fields.
Thematic Areas: Saúde coletiva Psicología Neurosciences Neurology (clinical) Neurology Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Engenharias iv Educação física Clinical neurology Ciências biológicas ii Ciências biológicas i Ciências ambientais
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: paloma.vicens@urv.cat cristian.cabrera@estudiants.urv.cat margarita.torrente@urv.cat
Author identifier: 0000-0003-0732-5070 0000-0002-8901-6345
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Current Alzheimer Research. 18 (13): 993-1009
APA: Cabrera, Cristian; Vicens, Paloma; Torrente, Margarita (2021). Modifiable Risk Factors for Dementia: The Role of Gut Microbiota. Current Alzheimer Research, 18(13), 993-1009. DOI: 10.2174/1567205018666211215152411
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV