Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Real-Time Monitoring of Doxorubicin Release from Hybrid Nanoporous Anodic Alumina Structures

  • Identification data

    Identifier: imarina:9241953
    Authors:
    Kapruwan, PankajFerre-Borrull, JosepMarsal, Lluis F
    Abstract:
    This work demonstrates an advanced approach to fabricate Hybrid nanoporous anodic alumina gradient-index filters (Hy-NAA-GIFs) through a heterogeneous anodization process combining sinusoidal current-density anodization and constant potential anodization. As a result, the hybrid structure obtained reveals a single photonic stopband (PSB), which falls within the absorption region of the drug molecule and the intensity of the spectrum that are far from such absorption range. The prepared structures were loaded with the doxorubicin (DOX) drug through the drop-casting method, which allows for evaluating the maximum reflectance of the relative height of the PSB with the average reflectance of the spectrum intensity. Thereafter, this property has been applied in a flow cell setup connected to a reflectance spectrophotometer where different drug-loaded samples were placed to study the behavior and kinetics of the drug release in real-time by varying two parameters, i.e., different pore length and flow rates. As such, obtained results were analyzed with a model that includes a sum of two inverted exponential decay functions with two different characteristic time releases. Overall, this study opens up several possibilities for the Hy-NAA-GIFs to study the drug kinetics from nanoporous structures.
  • Others:

    Author, as appears in the article.: Kapruwan, Pankaj; Ferre-Borrull, Josep; Marsal, Lluis F
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Ferré Borrull, José / Kapruwan, Pankaj / Marsal Garví, Luis Francisco
    Keywords: Targeted drug delivery Stopband Reflection Reflectance spectroscopy Real?time monitoring Real-time monitoring Real time monitoring Porous silicon Platform Photonic crystals Optics and photonics Nanoporous anodic aluminas Nanopores Morphology Kinetics Implants Hybrid nanoporous anodic alumina gradient?index filters Hybrid nanoporous anodic alumina gradient?index filter Hybrid nanoporous anodic alumina gradient-index filters Gradient-index filters Electrodes Doxorubicin Delivery Controlled drug delivery Bone Anodizations Anodization process Aluminum sheet Aluminum oxide Alumina structure Alumina Absorption spectroscopy
    Abstract: This work demonstrates an advanced approach to fabricate Hybrid nanoporous anodic alumina gradient-index filters (Hy-NAA-GIFs) through a heterogeneous anodization process combining sinusoidal current-density anodization and constant potential anodization. As a result, the hybrid structure obtained reveals a single photonic stopband (PSB), which falls within the absorption region of the drug molecule and the intensity of the spectrum that are far from such absorption range. The prepared structures were loaded with the doxorubicin (DOX) drug through the drop-casting method, which allows for evaluating the maximum reflectance of the relative height of the PSB with the average reflectance of the spectrum intensity. Thereafter, this property has been applied in a flow cell setup connected to a reflectance spectrophotometer where different drug-loaded samples were placed to study the behavior and kinetics of the drug release in real-time by varying two parameters, i.e., different pore length and flow rates. As such, obtained results were analyzed with a model that includes a sum of two inverted exponential decay functions with two different characteristic time releases. Overall, this study opens up several possibilities for the Hy-NAA-GIFs to study the drug kinetics from nanoporous structures.
    Thematic Areas: Zootecnia / recursos pesqueiros Química Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinar Instruments & instrumentation Instrumentation Information systems Geografía Geociências Farmacia Engineering, electrical & electronic Engenharias iv Engenharias iii Engenharias ii Engenharias i Electrochemistry Electrical and electronic engineering Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Biochemistry Atomic and molecular physics, and optics Astronomia / física Arquitetura, urbanismo e design Analytical chemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: pankaj.kapruwan1@estudiants.urv.cat pankaj.kapruwan1@estudiants.urv.cat josep.ferre@urv.cat lluis.marsal@urv.cat
    Author identifier: 0000-0002-5210-5133 0000-0002-5976-1408
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1424-8220/21/23/7819
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Sensors. 21 (23): 7819-
    APA: Kapruwan, Pankaj; Ferre-Borrull, Josep; Marsal, Lluis F (2021). Real-Time Monitoring of Doxorubicin Release from Hybrid Nanoporous Anodic Alumina Structures. Sensors, 21(23), 7819-. DOI: 10.3390/s21237819
    Article's DOI: 10.3390/s21237819
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Analytical Chemistry,Atomic and Molecular Physics, and Optics,Biochemistry,Chemistry, Analytical,Electrical and Electronic Engineering,Electrochemistry,Engineering, Electrical & Electronic,Information Systems,Instrumentation,Instruments & Instrumentation,Medicine (Miscellaneous)
    Targeted drug delivery
    Stopband
    Reflection
    Reflectance spectroscopy
    Real?time monitoring
    Real-time monitoring
    Real time monitoring
    Porous silicon
    Platform
    Photonic crystals
    Optics and photonics
    Nanoporous anodic aluminas
    Nanopores
    Morphology
    Kinetics
    Implants
    Hybrid nanoporous anodic alumina gradient?index filters
    Hybrid nanoporous anodic alumina gradient?index filter
    Hybrid nanoporous anodic alumina gradient-index filters
    Gradient-index filters
    Electrodes
    Doxorubicin
    Delivery
    Controlled drug delivery
    Bone
    Anodizations
    Anodization process
    Aluminum sheet
    Aluminum oxide
    Alumina structure
    Alumina
    Absorption spectroscopy
    Zootecnia / recursos pesqueiros
    Química
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Linguística e literatura
    Letras / linguística
    Interdisciplinar
    Instruments & instrumentation
    Instrumentation
    Information systems
    Geografía
    Geociências
    Farmacia
    Engineering, electrical & electronic
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Electrochemistry
    Electrical and electronic engineering
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, analytical
    Biotecnología
    Biodiversidade
    Biochemistry
    Atomic and molecular physics, and optics
    Astronomia / física
    Arquitetura, urbanismo e design
    Analytical chemistry
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