Author, as appears in the article.: Kapruwan, Pankaj; Ferre-Borrull, Josep; Marsal, Lluis F
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Ferré Borrull, José / Kapruwan, Pankaj / Marsal Garví, Luis Francisco
Keywords: Targeted drug delivery Stopband Reflection Reflectance spectroscopy Real?time monitoring Real-time monitoring Real time monitoring Porous silicon Platform Photonic crystals Optics and photonics Nanoporous anodic aluminas Nanopores Morphology Kinetics Implants Hybrid nanoporous anodic alumina gradient?index filters Hybrid nanoporous anodic alumina gradient?index filter Hybrid nanoporous anodic alumina gradient-index filters Gradient-index filters Electrodes Doxorubicin Delivery Controlled drug delivery Bone Anodizations Anodization process Aluminum sheet Aluminum oxide Alumina structure Alumina Absorption spectroscopy
Abstract: This work demonstrates an advanced approach to fabricate Hybrid nanoporous anodic alumina gradient-index filters (Hy-NAA-GIFs) through a heterogeneous anodization process combining sinusoidal current-density anodization and constant potential anodization. As a result, the hybrid structure obtained reveals a single photonic stopband (PSB), which falls within the absorption region of the drug molecule and the intensity of the spectrum that are far from such absorption range. The prepared structures were loaded with the doxorubicin (DOX) drug through the drop-casting method, which allows for evaluating the maximum reflectance of the relative height of the PSB with the average reflectance of the spectrum intensity. Thereafter, this property has been applied in a flow cell setup connected to a reflectance spectrophotometer where different drug-loaded samples were placed to study the behavior and kinetics of the drug release in real-time by varying two parameters, i.e., different pore length and flow rates. As such, obtained results were analyzed with a model that includes a sum of two inverted exponential decay functions with two different characteristic time releases. Overall, this study opens up several possibilities for the Hy-NAA-GIFs to study the drug kinetics from nanoporous structures.
Thematic Areas: Zootecnia / recursos pesqueiros Química Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinar Instruments & instrumentation Instrumentation Information systems Geografía Geociências Farmacia Engineering, electrical & electronic Engenharias iv Engenharias iii Engenharias ii Engenharias i Electrochemistry Electrical and electronic engineering Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, analytical Biotecnología Biodiversidade Biochemistry Atomic and molecular physics, and optics Astronomia / física Arquitetura, urbanismo e design Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: pankaj.kapruwan1@estudiants.urv.cat pankaj.kapruwan1@estudiants.urv.cat josep.ferre@urv.cat lluis.marsal@urv.cat
Author identifier: 0000-0002-5210-5133 0000-0002-5976-1408
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Sensors. 21 (23): 7819-
APA: Kapruwan, Pankaj; Ferre-Borrull, Josep; Marsal, Lluis F (2021). Real-Time Monitoring of Doxorubicin Release from Hybrid Nanoporous Anodic Alumina Structures. Sensors, 21(23), 7819-. DOI: 10.3390/s21237819
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV