Author, as appears in the article.: Martín-Grau C; Deulofeu R; Orus NS; Arija V; on behalf of the ECLIPSES Study Group
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arija Val, Maria Victoria
Keywords: Third trimester pregnancy Stearic acid Smoking Second trimester pregnancy Saturated fatty acid Reference value Reference intervals Quantitative analysis Prospective study Pregnant woman Pregnancy Polyunsaturated fatty acid Plasma Physical activity Palmitoleic acid Palmitic acid Omega 6 fatty acid Omega 3 fatty acid Oleic acid Myristic acid Monounsaturated fatty acid Maternal nutrition Mass fragmentography Major clinical study Linoleic acid Lauric acid Individual c14-c24 Icosapentaenoic acid Human Gestational weight gain Gamma linolenic acid First trimester pregnancy Female Fatty acid status Fatty acid blood level Ethnicity Educational status Docosahexaenoic acid Developed country Cohort analysis Body mass Article Arachidonic acid Alcohol consumption Adult reference intervals pregnancy maternal nutrition health fatty acid status
Abstract: In the course of pregnancy, increasing importance is being placed on maintaining optimal fatty acid (FA) levels and particularly n-3 PUFAs to ensure correct fetal development. However, reference ranges for FA have been reported in only a few studies. Our objective is to provide quantitative reference intervals for SFAs, MUFAs, and PUFAs (n-6 and n-3) in a large population of healthy pregnant women from a developed country. A prospective study of pregnant women (n = 479) was conducted from the first trimester (T1) to the third trimester (T3). A total of 11 fatty acids were analyzed in serum by gas chromatography mass spectrometry and were expressed as absolute (µmol/L) and relative (percentage of total FA) concentration units. Serum concentrations of SFAs, MUFAs, n-6 PUFAs, n-3 PUFAs, various FA ratios, and the EFA index were determined. The reference intervals (2.5/97.5 percentiles) in absolute values from T1 ranged from 1884.32 to 8802.81 µmol/L for SFAs, from 959.91 to 2979.46 µmol/L for MUFAs, from 2325.77 to 7735.74 µmol/L for n-6 PUFAs, and from 129.01 to 495.58 µmol/L for n-3 PUFAs. These intervals mainly include the values of other studies from European populations. However, reference ranges vary according to some maternal factors. The FA levels proposed, obtained from a large sample of pregnant women, will be a useful tool for assessing the degree of adequacy of FAs in pregnant women and will help to carry out dietary interventions based on certain maternal factors. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: victoria.arija@urv.cat
Author identifier: 0000-0002-1758-0975
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 13 (11):
APA: Martín-Grau C; Deulofeu R; Orus NS; Arija V; on behalf of the ECLIPSES Study Group (2021). Trimester-specific reference ranges for saturated, monounsaturated and polyunsaturated fatty acids in serum of pregnant women: A cohort study from the eclipses group. Nutrients, 13(11), -. DOI: 10.3390/nu13114037
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV