Author, as appears in the article.: Mallol R; Vallvé JC; Solà R; Girona J; Bergmann S; Correig X; Rock E; Winklhofer-Roob BM; Rehues P; Guardiola M; Masana L; Ribalta J
Department: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
URV's Author/s: Correig Blanchar, Francesc Xavier / Girona Tell, Josefa / Guardiola Guionnet, Montserrat / MALLOL PARERA, ROGER / Masana Marín, Luis / Rehues Masip, Pere / Ribalta Vives, Josep / Solà Alberich, Rosa Maria / Vallvé Torrente, Joan Carles
Keywords: Statistical methods Risk factors Oxidative stress Nuclear magnetic resonance spectroscopy Nuclear magnetic resonance Nmr Metabolomics Metabolites Metabolism Mediation analysis Low molecular weight Lipoproteins Glutamate Different mechanisms Chronological age Cardiovascular disease Amino-acids Amino acids Aging Age-related disease subpopulations risk relevance profile nmr metabolomics metabolome markers lipoproteins ldl glutamate focus
Abstract: Aging is a major risk factor for metabolic impairment that may lead to age-related diseases such as cardiovascular disease. Different mechanisms that may explain the interplay between aging and lipoproteins, and between aging and low-molecular-weight metabolites (LMWMs), in the metabolic dysregulation associated with age-related diseases have been described separately. Here, we statistically evaluated the possible mediation effects of LMWMs on the relationships between chronological age and lipoprotein concentrations in healthy men ranging from 19 to 75 years of age. Relative and absolute concentrations of LMWMs and lipoproteins, respectively, were assessed by nuclear magnetic resonance (NMR) spectroscopy. Multivariate linear regression and mediation analysis were conducted to explore the associations between age, lipoproteins and LMWMs. The statistical significance of the identified mediation effects was evaluated using the bootstrapping technique, and the identified mediation effects were validated on a publicly available dataset. Chronological age was statistically associated with five lipoprotein classes and subclasses. The mediation analysis showed that serine mediated 24.1% (95% CI: 22.9 – 24.7) of the effect of age on LDL-P, and glutamate mediated 17.9% (95% CI: 17.6 – 18.5) of the effect of age on large LDL-P. In the publicly available data, glutamate mediated the relationship between age and an NMR-derived surrogate of cholesterol. Our results suggest that the age-related increase in LDL particles may be mediated by a decrease in the nonessential amino acid glutamate. Future studies may contribute to a better understanding of the potential biological role of glutamate and LDL particles in aging mechanisms and age-related diseases. © 2021 The Authors
Thematic Areas: Structural biology Medicina i Genetics Computer science applications Ciências biológicas ii Ciências biológicas i Biotecnología Biotechnology Biophysics Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: pere.rehues@urv.cat josefa.girona@urv.cat jc.vallve@urv.cat pere.rehues@urv.cat josefa.girona@urv.cat jc.vallve@urv.cat xavier.correig@urv.cat rosa.sola@urv.cat montse.guardiola@urv.cat luis.masana@urv.cat josep.ribalta@urv.cat
Author identifier: 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-6902-3054 0000-0002-8359-235X 0000-0002-9696-7384 0000-0002-0789-4954 0000-0002-8879-4719
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S2001037021004876
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Computational And Structural Biotechnology Journal. 19 6169-6178
APA: Mallol R; Vallvé JC; Solà R; Girona J; Bergmann S; Correig X; Rock E; Winklhofer-Roob BM; Rehues P; Guardiola M; Masana L; Ribalta J (2021). Statistical mediation of the relationships between chronological age and lipoproteins by nonessential amino acids in healthy men. Computational And Structural Biotechnology Journal, 19(), 6169-6178. DOI: 10.1016/j.csbj.2021.11.022
Article's DOI: 10.1016/j.csbj.2021.11.022
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV