Author, as appears in the article.: Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea T; Halford, Jason C G; Sjoedin, Anders; Bullo, Monica
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica
Keywords: Young adult; Weight maintenance; Weight loss; Valine; Triglycerides; Triacylglycerol blood level; Triacylglycerol; Sphingomyelins; Sphingomyelin; Satin; Satiety; Satiation; Prospective study; Prospective studies; Phosphatidylcholines; Phosphatidylcholine; Obesity; Middle aged; Metabolomics; Male; Major clinical study; Low density lipoprotein cholesterol level; Low density lipoprotein cholesterol; Low calorie diet; Linear models; Humans; Human; Female; Controlled study; Cholesterol, ldl; Cholesterol; Cardiovascular risk; Cardiometabolic risk factors; Cardiometabolic risk factor; Cardiometabolic risk; Caloric restriction; Body weight maintenance; Body weight loss; Body mass index; Article; Aged; Adult; weight maintenance; weight loss; satin; regain; metabolomics; intervention; disease; cardiometabolic risk; association
Abstract: (1) Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. (2) Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ?8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. (3) Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. (4) Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: monica.bullo@urv.cat
Record's date: 2024-10-12
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/13/12/4289
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 13 (12): 4289-
APA: Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea T; Halford, Jason C G; Sjoedin, Anders; Bullo, Monica (2021). Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk. Nutrients, 13(12), 4289-. DOI: 10.3390/nu13124289
Article's DOI: 10.3390/nu13124289
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV