Articles producció científica> Bioquímica i Biotecnologia

Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk

  • Identification data

    Identifier: imarina:9242260
    Authors:
    Papandreou, ChristopherHarrold, Joanne AHansen, Thea THalford, Jason C GSjoedin, AndersBullo, Monica
    Abstract:
    (1) Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. (2) Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ?8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. (3) Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. (4) Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
  • Others:

    Author, as appears in the article.: Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea T; Halford, Jason C G; Sjoedin, Anders; Bullo, Monica
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica
    Keywords: Young adult Weight maintenance Weight loss Valine Triglycerides Triacylglycerol blood level Triacylglycerol Sphingomyelins Sphingomyelin Satin Satiety Satiation Prospective study Prospective studies Phosphatidylcholines Phosphatidylcholine Obesity Middle aged Metabolomics Male Major clinical study Low density lipoprotein cholesterol level Low density lipoprotein cholesterol Low calorie diet Linear models Humans Human Female Controlled study Cholesterol, ldl Cholesterol Cardiovascular risk Cardiometabolic risk factors Cardiometabolic risk factor Cardiometabolic risk Caloric restriction Body weight maintenance Body weight loss Body mass index Article Aged Adult weight maintenance weight loss satin regain metabolomics intervention disease cardiometabolic risk association
    Abstract: (1) Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. (2) Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ?8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. (3) Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. (4) Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.bullo@urv.cat
    Author identifier: 0000-0002-0218-7046
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/12/4289
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (12): 4289-
    APA: Papandreou, Christopher; Harrold, Joanne A; Hansen, Thea T; Halford, Jason C G; Sjoedin, Anders; Bullo, Monica (2021). Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk. Nutrients, 13(12), 4289-. DOI: 10.3390/nu13124289
    Article's DOI: 10.3390/nu13124289
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Young adult
    Weight maintenance
    Weight loss
    Valine
    Triglycerides
    Triacylglycerol blood level
    Triacylglycerol
    Sphingomyelins
    Sphingomyelin
    Satin
    Satiety
    Satiation
    Prospective study
    Prospective studies
    Phosphatidylcholines
    Phosphatidylcholine
    Obesity
    Middle aged
    Metabolomics
    Male
    Major clinical study
    Low density lipoprotein cholesterol level
    Low density lipoprotein cholesterol
    Low calorie diet
    Linear models
    Humans
    Human
    Female
    Controlled study
    Cholesterol, ldl
    Cholesterol
    Cardiovascular risk
    Cardiometabolic risk factors
    Cardiometabolic risk factor
    Cardiometabolic risk
    Caloric restriction
    Body weight maintenance
    Body weight loss
    Body mass index
    Article
    Aged
    Adult
    weight maintenance
    weight loss
    satin
    regain
    metabolomics
    intervention
    disease
    cardiometabolic risk
    association
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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