Articles producció científica> Ciències Mèdiques Bàsiques

First report of an invasive infection by cephalotrichum gorgonifer in a neutropenic patient with hematological malignancy under chemotherapy

  • Identification data

    Identifier: imarina:9242324
    Authors:
    Álvarez?uría AEscribano PParra?blanco VCano?lira JFStchigel AMOarbeascoa GMuñoz PGuinea J
    Abstract:
    The etiological agents of infrequent invasive fungal infections (IFI) are difficult to identify on the species level using classic morphological examination. We describe the first case of an IFI caused by Cephalotrichum gorgonifer in a neutropenic patient with a hematological malignancy and put it on the map as a new causative agent of IFI. Case report, microbiological findings and description of the etiological agent. A 60?year?old man was diagnosed with mantle cell lymphoma. A CT scan confirmed the presence of lung infiltrates located at the right upper lobe. Histological examination of one of the nodules showed a large number of narrow septate hyphae with acute?angle branching and irregular round cell morphology; vessels walls appeared infiltrated, proving an angioinvasive pulmonary IFI. Sample culture resulted positive and molecular identification proved the presence of Cephalotrichum gorgonifer. Voriconazole was used for 12 months and the patient did not report any complications or side effects. Complete remission of lymphoma was achieved later by the time chemotherapy, radiotherapy, and radioimmunotherapy consolidation were completed. We recommend the inclusion of Cephalotrichum gorgonifer in the list of opportunistic pathogens causing mycoses in neutropenic hematological patients with suspected mould?related IFI. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
  • Others:

    Author, as appears in the article.: Álvarez?uría A; Escribano P; Parra?blanco V; Cano?lira JF; Stchigel AM; Oarbeascoa G; Muñoz P; Guinea J
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Cano Lira, José Francisco / Stchigel Glikman, Alberto Miguel
    Keywords: Neutropenia Molecular identification Invasive fungal infection Diagnosis Cephalotrichum gorgonifer Cell transplant recipients neutropenia molecular identification invasive fungal infection epidemiology diagnosis
    Abstract: The etiological agents of infrequent invasive fungal infections (IFI) are difficult to identify on the species level using classic morphological examination. We describe the first case of an IFI caused by Cephalotrichum gorgonifer in a neutropenic patient with a hematological malignancy and put it on the map as a new causative agent of IFI. Case report, microbiological findings and description of the etiological agent. A 60?year?old man was diagnosed with mantle cell lymphoma. A CT scan confirmed the presence of lung infiltrates located at the right upper lobe. Histological examination of one of the nodules showed a large number of narrow septate hyphae with acute?angle branching and irregular round cell morphology; vessels walls appeared infiltrated, proving an angioinvasive pulmonary IFI. Sample culture resulted positive and molecular identification proved the presence of Cephalotrichum gorgonifer. Voriconazole was used for 12 months and the patient did not report any complications or side effects. Complete remission of lymphoma was achieved later by the time chemotherapy, radiotherapy, and radioimmunotherapy consolidation were completed. We recommend the inclusion of Cephalotrichum gorgonifer in the list of opportunistic pathogens causing mycoses in neutropenic hematological patients with suspected mould?related IFI. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
    Thematic Areas: Plant science Mycology Microbiology (medical) Microbiology Farmacia Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: albertomiguel.stchigel@urv.cat jose.cano@urv.cat
    Author identifier: 0000-0003-3987-7996 0000-0003-4495-4394
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2309-608X/7/12/1089
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: J Fungi (Basel). 7 (12):
    APA: Álvarez?uría A; Escribano P; Parra?blanco V; Cano?lira JF; Stchigel AM; Oarbeascoa G; Muñoz P; Guinea J (2021). First report of an invasive infection by cephalotrichum gorgonifer in a neutropenic patient with hematological malignancy under chemotherapy. J Fungi (Basel), 7(12), -. DOI: 10.3390/jof7121089
    Article's DOI: 10.3390/jof7121089
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Ecology, Evolution, Behavior and Systematics,Microbiology,Microbiology (Medical),Mycology,Plant Science
    Neutropenia
    Molecular identification
    Invasive fungal infection
    Diagnosis
    Cephalotrichum gorgonifer
    Cell transplant recipients
    neutropenia
    molecular identification
    invasive fungal infection
    epidemiology
    diagnosis
    Plant science
    Mycology
    Microbiology (medical)
    Microbiology
    Farmacia
    Ecology, evolution, behavior and systematics
    Ciências biológicas iii
    Ciências biológicas ii
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