Author, as appears in the article.: Galie, Serena; Papandreou, Christopher; Arcelin, Pierre; Garcia, David; Palau-Galindo, Antoni; Gutierrez-Tordera, Laia; Folch, Alex; Bullo, Monica
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Galiè, Serena
Keywords: Rna, ribosomal, 16s; Risk; Randomized controlled trials as topic; Omics; Obesity; Middle aged; Microbial metabolites; Metagenomics; Metabolomics; Metabolites; Metabolism; Metabolic syndrome; Male; Lipids; Lipid metabolism; Humans; Host microbial interactions; Gut microbiota; Gastrointestinal microbiome; Female; Feces; Diet; Cross-talk; Cross-sectional studies; Cross-over studies; Cardiovascular risk; Cardiometabolic risk factors; Canonical correlation analysis; Association; Aged; Adult; Acid
Abstract: (1) Background: The microbiota-host cross-talk has been previously investigated, while its role in health is not yet clear. This study aimed to unravel the network of microbial-host interactions and correlate it with cardiometabolic risk factors. (2) Methods: A total of 47 adults with overweight/obesity and metabolic syndrome from the METADIET study were included in this cross-sectional analysis. Microbiota composition (151 genera) was assessed by 16S rRNA sequencing, fecal (m = 203) and plasma (m = 373) metabolites were profiled. An unsupervised sparse generalized canonical correlation analysis was used to construct a network of microbiota-metabolite interactions. A multi-omics score was derived for each cluster of the network and associated with cardiometabolic risk factors. (3) Results: Five multi-omics clusters were identified. Thirty-one fecal metabolites formed these clusters and were correlated with plasma sphingomyelins, lysophospholipids and medium to long-chain acylcarnitines. Seven genera from Ruminococcaceae and a member from the Desulfovibrionaceae family were correlated with fecal and plasma metabolites. Positive correlations were found between the multi-omics scores from two clusters with cholesterol and triglycerides levels. (4) Conclusions: We identified a correlated network between specific microbial genera and fecal/plasma metabolites in an adult population with metabolic syndrome, suggesting an interplay between gut microbiota and host lipid metabolism on cardiometabolic health.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: monica.bullo@urv.cat
Record's date: 2024-10-12
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/13/12/4318
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 13 (12): 4318-
APA: Galie, Serena; Papandreou, Christopher; Arcelin, Pierre; Garcia, David; Palau-Galindo, Antoni; Gutierrez-Tordera, Laia; Folch, Alex; Bullo, Monica (2021). Examining the Interaction of the Gut Microbiome with Host Metabolism and Cardiometabolic Health in Metabolic Syndrome. Nutrients, 13(12), 4318-. DOI: 10.3390/nu13124318
Article's DOI: 10.3390/nu13124318
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV