Author, as appears in the article.: Deepika, Deepika; Rovira, Joaquim; Sabuz, Oscar; Balaguer, Jordina; Schuhmacher, Marta; Domingo, Jose L; Kumar, Vikas
Department: Enginyeria Química
URV's Author/s: Balaguer Trias, Jordina / Domingo Roig, José Luis / Kumar, Vikas / Rovira Solano, Joaquim / Sabuz Vidal, Oscar / Schuhmacher Ansuategui, Marta
Keywords: Translational in silico models Toxicokinetic model Systematic analysis Risk assessment Regulatory limits Pfos Pfoa Pfas Perfluorinated compounds Human biomonitoring Health effects Fluorocarbons Environmental pollutants Dietary toxicity Computer simulation Animals Alkanesulfonic acids translational in silico models toxicokinetic model systematic analysis substances regulatory limits pfos pfoa pfas perfluorooctanesulfonate life human biomonitoring health effects exposure
Abstract: Perfluoroalkyl substances (PFAS), especially PFOS and PFOA, are two widely used synthetic chemicals that can impact human health based on evidence from animal and epidemiologic studies. In this paper, we have reviewed and summarized the influence of PFAS exposure on health, pointing the quality of evidence, and applied translational techniques to integrate evidence for PFAS policy making. This is the first review where highly referred articles on PFAS used for policymaking by several regulatory agencies were collected and evaluated based on the review guidelines developed by the US National Toxicology Program's Office of Health Assessment and Translation (OHAT) review guidelines. Several limitations were observed, including co-exposure to multiple chemicals and limited measurement of primary and secondary outcomes related to specific toxicity. However, data from all the studies provided a moderate to strong level of confidence for link between PFAS exposure and different adverse outcomes. Secondly, for translating the risk to humans, an in-silico model and scaling approach was utilized. Physiologically based pharmacokinetic model (PBPK) was used to calculate the human equivalent dose (HED) from two widely accepted studies and compared with tolerable daily intakes (TDIs) established by various regulatory agencies. Inter-species dose extrapolation was done to compare with human the relevance of dosing scenarios used in animals. Overall, a framework for translation of risk was proposed based on the conclusions of this review with the goal of improving policymaking. The current paper can improve the methodological protocols for PFAS experimental studies and encourage the utilization of in-silico models for translating risk.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: oscar.sabuz@urv.cat vikas.kumar@urv.cat joaquim.rovira@urv.cat jordina.balaguer@estudiants.urv.cat jordina.balaguer@estudiants.urv.cat oscar.sabuz@urv.cat joseluis.domingo@urv.cat marta.schuhmacher@urv.cat
Author identifier: 0000-0002-9795-5967 0000-0003-4399-6138 0000-0001-9001-207X 0000-0001-9001-207X 0000-0001-6647-9470 0000-0003-4381-2490
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environmental Research. 208 112722-112722
APA: Deepika, Deepika; Rovira, Joaquim; Sabuz, Oscar; Balaguer, Jordina; Schuhmacher, Marta; Domingo, Jose L; Kumar, Vikas (2022). Framework for risk assessment of PFAS utilizing experimental studies and in-silico models. Environmental Research, 208(), 112722-112722. DOI: 10.1016/j.envres.2022.112722
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV