Author, as appears in the article.: Valls RM; Companys J; Calderón-Pérez L; Salamanca P; Pla-Pagà L; Sandoval-Ramírez BA; Bueno A; Puzo J; Crescenti A; Del Bas JM; Caimari A; Salamanca A; Espinel AE; Pedret A; Arola L; Solà R
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Arola Ferrer, Luis Maria / Companys Alemany, Judit / Pedret Figuerola, Anna / Salamanca González, Patricia / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: S-allyl-l-cysteine Pulse pressure Hypercholesterolemia High blood-pressure Cardiovascular disease risk factor Blood pressure Aged garlic extract s-allyl-l-cysteine pulse pressure metaanalysis mechanisms in-vitro hypertensives hypercholesterolemia cardiovascular disease risk factor blood pressure allium-sativum adults
Abstract: The consumption of aged black garlic (ABG) has been related to improvements in several cardiovascular disease (CVD) risk factors. However, the extent of the beneficial effects depends on the garlic aging process and the amount and type of chemical compounds accumulated. The main objective of this study was to assess the effect of daily intake of a well-characterized ABG extract with a standardized S-allyl-L-cysteine (SAC) yield in combination with dietary recommendations regarding CVD risk factors in individuals with moderate hypercholesterolemia. Sixty-seven hypercholesterolemic individuals with low-density lipoprotein cholesterol levels ≥115 mg/dL were randomized in a crossover, double-blind, sustained, and controlled intervention study. The participants consumed 250 mg (1.25 mg SAC)/tablet/day ABG or a placebo for 6 weeks, with 3 weeks of washout. Blood and pulse pressure and other CVD risk biomarkers were determined at the beginning and end of each intervention. At 6 weeks, ABG extract reduced diastolic blood pressure (DBP) (mean (95% CI) −5.85 (−10.5; −1.3) mm Hg) compared to the placebo, particularly in men with a DBP > 75 mm Hg. The consumption of an improved ABG extract with 1.25 mg of SAC decreased DBP, particularly in men with moderate hypercholesterolemia. The potential beneficial effects of ABG may contribute to obtaining an optimal DBP.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: judit.companys@urv.cat anna.pedret@urv.cat patricia.salamanca@estudiants.urv.cat patricia.salamanca@estudiants.urv.cat judit.companys@urv.cat judit.companys@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
Author identifier: 0000-0003-1485-0818 0000-0002-5327-932X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/3/405
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (3):
APA: Valls RM; Companys J; Calderón-Pérez L; Salamanca P; Pla-Pagà L; Sandoval-Ramírez BA; Bueno A; Puzo J; Crescenti A; Del Bas JM; Caimari A; Salamanca A (2022). Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study. Nutrients, 14(3), -. DOI: 10.3390/nu14030405
Article's DOI: 10.3390/nu14030405
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV