Articles producció científica> Enginyeria Química

Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity

  • Identification data

    Identifier: imarina:9243758
    Handle: http://hdl.handle.net/20.500.11797/imarina9243758
  • Authors:

    Balaguer-Trias J
    Deepika D
    Schuhmacher M
    Kumar V
  • Others:

    Author, as appears in the article.: Balaguer-Trias J; Deepika D; Schuhmacher M; Kumar V
    Department: Enginyeria Química
    URV's Author/s: Balaguer Trias, Jordina / Kumar, Vikas / Schuhmacher Ansuategui, Marta
    Keywords: Pfas Neurotoxicity In-vivo In-silico Gut microbiota Dehp Chlorpyrifos Bpa Bisphenol-a system risk pfas neurotoxicity metabolism maturation in-silico health gut microbiota diet dehp chlorpyrifos bpa
    Abstract: Over the last years, research has focused on microbiota to establish a missing link between neuronal health and intestine imbalance. Many studies have considered microbiota as critical regulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system is mainly explained through three different pathways: the neural, endocrine, and immune pathways, intricately interconnected with each other. In day-to-day life, human beings are exposed to a wide variety of contaminants that affect our intestinal microbiota and alter the bidirectional communication between the gut and brain, causing neuronal disorders. The interplay between xenobiotics, microbiota and neurotoxicity is still not fully explored, especially for susceptible populations such as pregnant women, neonates, and developing children. Precisely, early exposure to contaminants can trigger neurodevelopmental toxicity and long-term diseases. There is growing but limited research on the specific mechanisms of the microbiota–gut–brain axis (MGBA), making it challenging to understand the effect of environmental pollutants. In this review, we discuss the biological interplay between microbiota–gut–brain and analyse the role of endocrine-disrupting chemicals: Bisphenol A (BPA), Chlorpyrifos (CPF), Diethylhexyl phthalate (DEHP), and Per-and polyfluoroalkyl substances (PFAS) in MGBA perturbations and subsequent neurotoxicity. The complexity of the MGBA and the changing nature of the gut microbiota pose significant challenges for future research. However, emerging in-silico models able to analyse and interpret meta-omics data are a promising option for understanding the processes in this axis and can help prevent neurotoxicity.
    Thematic Areas: Zootecnia / recursos pesqueiros Serviço social Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Pollution Odontología Nutrição Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Health, toxicology and mutagenesis Geografía Geociências Farmacia Environmental sciences Ensino Engenharias ii Engenharias i Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: vikas.kumar@urv.cat jordina.balaguer@urv.cat marta.schuhmacher@urv.cat jordina.balaguer@urv.cat
    Author identifier: 0000-0002-9795-5967 0000-0001-9001-207X 0000-0003-4381-2490 0000-0001-9001-207X
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1660-4601/19/3/1368
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Environmental Research And Public Health. 19 (3):
    APA: Balaguer-Trias J; Deepika D; Schuhmacher M; Kumar V (2022). Impact of Contaminants on Microbiota: Linking the Gut–Brain Axis with Neurotoxicity. International Journal Of Environmental Research And Public Health, 19(3), -. DOI: 10.3390/ijerph19031368
    Article's DOI: 10.3390/ijerph19031368
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Environmental Sciences,Health, Toxicology and Mutagenesis,Pollution,Public Health, Environmental and Occupational Health,Public, Environmental & Occupational Health
    Pfas
    Neurotoxicity
    In-vivo
    In-silico
    Gut microbiota
    Dehp
    Chlorpyrifos
    Bpa
    Bisphenol-a
    system
    risk
    pfas
    neurotoxicity
    metabolism
    maturation
    in-silico
    health
    gut microbiota
    diet
    dehp
    chlorpyrifos
    bpa
    Zootecnia / recursos pesqueiros
    Serviço social
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Pollution
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Health, toxicology and mutagenesis
    Geografía
    Geociências
    Farmacia
    Environmental sciences
    Ensino
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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