Articles producció científica> Medicina i Cirurgia

Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes

  • Identification data

    Identifier: imarina:9244518
    Authors:
    Auguet, TeresaLopez-Dupla, MiguelRamos, JessicaBertran, LaiaRiesco, DavidAguilar, CarmenArdevol, AnnaPinent, MontserratSabench, FatimaDel Castillo, DanielRichart, Cristobal
    Abstract:
    Many patients with clinically severe obesity (CSO) need to undergo bariatric surgery, with possible side effects, so individualized predictive methods are required. Adipocytokines and gut/intestinal microbiota-derived metabolites could be predictive biomarkers of metabolic success post- surgery, but the knowledge in this field is undefined. The objective of this work was to determine whether adipocytokines and microbiota-derived metabolites can be used to predict the metabolic improvement post- surgery in women with CSO. We analyzed circulating levels of some cytokines and some microbiota-derived metabolites at baseline and 12 months post-surgery from 44 women with CSO and 21 women with normal weight. Results showed that glucose, insulin, glycosylated hemoglobin A1c (HbA1c), low-density lipoprotein (LDL-C), and triglycerides levels were decreased post-surgery, while high density lipoprotein increased. Twelve months later, leptin, resistin, lipocalin, PAI-1, TNF-alpha, and IL-1 beta levels were lower than baseline, meanwhile adiponectin, IL-8, and IL-10 levels were increased. Moreover, baseline lipocalin levels were associated with HbA1c reduction post-surgery; meanwhile baseline resistin was related to postoperative HOMA2 (insulin resistance) and baseline propionate was associated with LDL-C decrease. To conclude, the detection of lipocalin, resistin, and propionate levels may be used to predict the metabolic success following bariatric surgery, although new knowledge is needed.
  • Others:

    Author, as appears in the article.: Auguet, Teresa; Lopez-Dupla, Miguel; Ramos, Jessica; Bertran, Laia; Riesco, David; Aguilar, Carmen; Ardevol, Anna; Pinent, Montserrat; Sabench, Fatima; Del Castillo, Daniel; Richart, Cristobal
    Department: Medicina i Cirurgia Bioquímica i Biotecnologia
    URV's Author/s: Aguilar Crespillo, Carmen Isabel / Ardévol Grau, Anna / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Del Castillo Déjardin, Daniel / López Dupla, Jesús Miguel / Pinent Armengol, Montserrat / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima
    Keywords: Y-gastric bypass Weight-loss Obesity Microbiota Mechanisms Laparoscopic sleeve gastrectomy Inflammation Diabetes remission Biomarker Bariatric surgery Adipocytokines
    Abstract: Many patients with clinically severe obesity (CSO) need to undergo bariatric surgery, with possible side effects, so individualized predictive methods are required. Adipocytokines and gut/intestinal microbiota-derived metabolites could be predictive biomarkers of metabolic success post- surgery, but the knowledge in this field is undefined. The objective of this work was to determine whether adipocytokines and microbiota-derived metabolites can be used to predict the metabolic improvement post- surgery in women with CSO. We analyzed circulating levels of some cytokines and some microbiota-derived metabolites at baseline and 12 months post-surgery from 44 women with CSO and 21 women with normal weight. Results showed that glucose, insulin, glycosylated hemoglobin A1c (HbA1c), low-density lipoprotein (LDL-C), and triglycerides levels were decreased post-surgery, while high density lipoprotein increased. Twelve months later, leptin, resistin, lipocalin, PAI-1, TNF-alpha, and IL-1 beta levels were lower than baseline, meanwhile adiponectin, IL-8, and IL-10 levels were increased. Moreover, baseline lipocalin levels were associated with HbA1c reduction post-surgery; meanwhile baseline resistin was related to postoperative HOMA2 (insulin resistance) and baseline propionate was associated with LDL-C decrease. To conclude, the detection of lipocalin, resistin, and propionate levels may be used to predict the metabolic success following bariatric surgery, although new knowledge is needed.
    Thematic Areas: Process chemistry and technology Engineering, chemical Engenharias ii Ciências biológicas ii Chemical engineering (miscellaneous) Bioengineering
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: davidgerardo.riesco@urv.cat danieldel.castillo@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat anna.ardevol@urv.cat fatima.sabench@urv.cat montserrat.pinent@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat jesusmiguel.lopez@urv.cat
    Author identifier: 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9052-1368 0000-0001-9052-1368 0000-0003-0156-7538 0000-0002-9262-8756 0000-0003-3550-5378 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428 0000-0002-9141-2523
    Record's date: 2024-09-28
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2227-9717/10/1/143
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Processes. 10 (1): 143-
    APA: Auguet, Teresa; Lopez-Dupla, Miguel; Ramos, Jessica; Bertran, Laia; Riesco, David; Aguilar, Carmen; Ardevol, Anna; Pinent, Montserrat; Sabench, Fatima (2022). Lipocalin, Resistin and Gut Microbiota-Derived Propionate Could Be Used to Predict Metabolic Bariatric Surgery Selected Outcomes. Processes, 10(1), 143-. DOI: 10.3390/pr10010143
    Article's DOI: 10.3390/pr10010143
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Bioengineering,Chemical Engineering (Miscellaneous),Engineering, Chemical,Process Chemistry and Technology
    Y-gastric bypass
    Weight-loss
    Obesity
    Microbiota
    Mechanisms
    Laparoscopic sleeve gastrectomy
    Inflammation
    Diabetes remission
    Biomarker
    Bariatric surgery
    Adipocytokines
    Process chemistry and technology
    Engineering, chemical
    Engenharias ii
    Ciências biológicas ii
    Chemical engineering (miscellaneous)
    Bioengineering
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