Author, as appears in the article.: Grau-Bove, Carme; Grau-Bove, Xavier; Terra, Ximena; Garcia-Vallve, Santi; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Teresa Blay, M; Ardevol, Anna; Pinent, Montserrat
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Garcia Vallve, Santiago / GRAU BOVÉ, FRANCESC XAVIER / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
Keywords: Taste buds Taste Reveals Receptors, g-protein-coupled Phylogeny Humans Htas2r5 Genomics Bitter taste receptor Animals Agonist assays selectivity ranges chemoreceptors bitter taste receptor
Abstract: Bitterness is perceived in humans by 25 subtypes of bitter taste receptors (hTAS2R) that range from broadly tuned to more narrowly tuned receptors. hTAS2R5 is one of the most narrowly tuned bitter taste receptors in humans. In this study, we review the literature on this receptor and show there is no consensus about its role. We then compare the possible role of hTAS2R5 with that of the proteins of the TAS2R family in rat, mouse, and pig. A phylogenetic tree of all mammalian TAS2R domain-containing proteins showed that human hTAS2R5 has no ortholog in pig, mouse, or rat genomes. By comparing the agonists that are common to hTAS2R5 and other members of the family, we observed that hTAS2R39 is the receptor that shares most agonists with hTAS2R5. In mouse, some of these agonists activate mTas2r105 and mTas2r144, which are distant paralogs of hTAS2R5. mTas2r144 seems to be the receptor that is most similar to hTAS2R5 because they are both activated by the same agonists and have affinities in the same range of values. Then, we can conclude that hTAS2R5 has a unique functional specificity in humans as it is activated by selective agonists and that its closest functional homolog in mouse is the phylogenetically distant mTas2r144.© 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Genetics General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Cell biology Biotecnología Biotechnology Biology Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat santi.garcia-vallve@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0002-0348-7497 0000-0001-9691-1906
Record's date: 2024-10-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202101128RR
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Faseb Journal. 36 (3): e22175-e22175
APA: Grau-Bove, Carme; Grau-Bove, Xavier; Terra, Ximena; Garcia-Vallve, Santi; Rodriguez-Gallego, Esther; Beltran-Debon, Raul; Teresa Blay, M; Ardevol, Ann (2022). Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5. Faseb Journal, 36(3), e22175-e22175. DOI: 10.1096/fj.202101128RR
Article's DOI: 10.1096/fj.202101128RR
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV