Articles producció científica> Bioquímica i Biotecnologia

Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5

  • Identification data

    Identifier: imarina:9244565
  • Authors:

    Grau-Bové C
    Grau-Bové X
    Terra X
    Garcia-Vallve S
    Rodríguez-Gallego E
    Beltran-Debón R
    Blay MT
    Ardévol A
    Pinent M
  • Others:

    Author, as appears in the article.: Grau-Bové C; Grau-Bové X; Terra X; Garcia-Vallve S; Rodríguez-Gallego E; Beltran-Debón R; Blay MT; Ardévol A; Pinent M
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Garcia Vallve, Santiago / GRAU BOVÉ, FRANCESC XAVIER / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Terra Barbadora, Ximena
    Keywords: Taste buds Taste Reveals Receptors, g-protein-coupled Phylogeny Humans Htas2r5 Genomics Bitter taste receptor Animals Agonist assays selectivity ranges chemoreceptors bitter taste receptor
    Abstract: Bitterness is perceived in humans by 25 subtypes of bitter taste receptors (hTAS2R) that range from broadly tuned to more narrowly tuned receptors. hTAS2R5 is one of the most narrowly tuned bitter taste receptors in humans. In this study, we review the literature on this receptor and show there is no consensus about its role. We then compare the possible role of hTAS2R5 with that of the proteins of the TAS2R family in rat, mouse, and pig. A phylogenetic tree of all mammalian TAS2R domain-containing proteins showed that human hTAS2R5 has no ortholog in pig, mouse, or rat genomes. By comparing the agonists that are common to hTAS2R5 and other members of the family, we observed that hTAS2R39 is the receptor that shares most agonists with hTAS2R5. In mouse, some of these agonists activate mTas2r105 and mTas2r144, which are distant paralogs of hTAS2R5. mTas2r144 seems to be the receptor that is most similar to hTAS2R5 because they are both activated by the same agonists and have affinities in the same range of values. Then, we can conclude that hTAS2R5 has a unique functional specificity in humans as it is activated by selective agonists and that its closest functional homolog in mouse is the phylogenetically distant mTas2r144.© 2022 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.
    Thematic Areas: Saúde coletiva Química Psicología Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Genetics General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Cell biology Biotecnología Biotechnology Biology Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: anna.ardevol@urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat santi.garcia-vallve@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0003-0156-7538 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0002-0348-7497 0000-0001-9691-1906
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202101128RR
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Faseb Journal. 36 (3): e22175-e22175
    APA: Grau-Bové C; Grau-Bové X; Terra X; Garcia-Vallve S; Rodríguez-Gallego E; Beltran-Debón R; Blay MT; Ardévol A; Pinent M (2022). Functional and genomic comparative study of the bitter taste receptor family TAS2R: Insight into the role of human TAS2R5. Faseb Journal, 36(3), e22175-e22175. DOI: 10.1096/fj.202101128RR
    Article's DOI: 10.1096/fj.202101128RR
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Biology,Biotechnology,Cell Biology,Genetics,Medicine (Miscellaneous),Molecular Biology
    Taste buds
    Taste
    Reveals
    Receptors, g-protein-coupled
    Phylogeny
    Humans
    Htas2r5
    Genomics
    Bitter taste receptor
    Animals
    Agonist assays
    selectivity
    ranges
    chemoreceptors
    bitter taste receptor
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Genetics
    General medicine
    Farmacia
    Engenharias iv
    Engenharias ii
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Cell biology
    Biotecnología
    Biotechnology
    Biology
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
    Astronomia / física
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