Articles producció científica> Bioquímica i Biotecnologia

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

  • Identification data

    Identifier: imarina:9245541
    Authors:
    Tresserra-Rimbau ACastro-Barquero SBecerra-Tomás NBabio NMartínez-González MÁCorella DFitó MRomaguera DVioque JAlonso-Gomez AMWärnberg JMartínez JASerra-Majem LEstruch RTinahones FJLapetra JPintó XTur JALópez-Miranda JCano-Ibáñez NDelgado-Rodríguez MMatía-Martín PDaimiel LSánchez VMVidal JVázquez CRos EBasterra FJde la Puente MFAsensio EMCastañer OBullón-Vela VTojal-Sierra LGómez-Gracia ECases-Pérez EKonieczna JGarcía-Ríos ACasañas-Quintana TBernal-Lopez MRSantos-Lozano JMEsteve-Luque VBouzas CVázquez-Ruiz ZPalau-Galindo ABarragan RGrau MLRazquín CGoicolea-Güemez LToledo EVergaz MVLamuela-Raventós RMSalas-Salvadó J
    Abstract:
    Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a vali-dated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
  • Others:

    Author, as appears in the article.: Tresserra-Rimbau A; Castro-Barquero S; Becerra-Tomás N; Babio N; Martínez-González MÁ; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gomez AM; Wärnberg J; Martínez JA; Serra-Majem L; Estruch R; Tinahones FJ; Lapetra J; Pintó X; Tur JA; López-Miranda J; Cano-Ibáñez N; Delgado-Rodríguez M; Matía-Martín P; Daimiel L; Sánchez VM; Vidal J; Vázquez C; Ros E; Basterra FJ; de la Puente MF; Asensio EM; Castañer O; Bullón-Vela V; Tojal-Sierra L; Gómez-Gracia E; Cases-Pérez E; Konieczna J; García-Ríos A; Casañas-Quintana T; Bernal-Lopez MR; Santos-Lozano JM; Esteve-Luque V; Bouzas C; Vázquez-Ruiz Z; Palau-Galindo A; Barragan R; Grau ML; Razquín C; Goicolea-Güemez L; Toledo E; Vergaz MV; Lamuela-Raventós RM; Salas-Salvadó J
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Palau Galindo, Antonio / Salas Salvadó, Jorge
    Keywords: Phenolic acids Obesity Metabolic syndrome Mediterranean diet Hba1c Glycosylated hemoglobin Glucose Flavonoids Cardiometabolic risk Antioxidants type-2 supplementation prevention phenolic acids obesity metabolic syndrome metaanalysis mediterranean diet hba1c glycosylated hemoglobin glucose flavonoids consumption
    Abstract: Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a vali-dated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
    Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: antonio.palau@urv.cat nerea.becerra@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-4429-6507 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-3921/11/2/316
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Antioxidants. 11 (2):
    APA: Tresserra-Rimbau A; Castro-Barquero S; Becerra-Tomás N; Babio N; Martínez-González MÁ; Corella D; Fitó M; Romaguera D; Vioque J; Alonso-Gomez AM; Wärn (2022). Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial. Antioxidants, 11(2), -. DOI: 10.3390/antiox11020316
    Article's DOI: 10.3390/antiox11020316
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Phenolic acids
    Obesity
    Metabolic syndrome
    Mediterranean diet
    Hba1c
    Glycosylated hemoglobin
    Glucose
    Flavonoids
    Cardiometabolic risk
    Antioxidants
    type-2
    supplementation
    prevention
    phenolic acids
    obesity
    metabolic syndrome
    metaanalysis
    mediterranean diet
    hba1c
    glycosylated hemoglobin
    glucose
    flavonoids
    consumption
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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