Author, as appears in the article.: Perpinan, Carles; Bertran, Laia; Terra, Ximena; Aguilar, Carmen; Binetti, Jessica; Lopez-Dupla, Miguel; Rull, Anna; Reverte, Laia; Yeregui, Elena; Gomez-Bertomeu, Frederic; Peraire, Joaquim; Auguet, Teresa
Department: Bioquímica i Biotecnologia Medicina i Cirurgia
URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Gomez Bertomeu, Frederic-Francesc / López Dupla, Jesús Miguel / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Terra Barbadora, Ximena / Yeregui Etxeberria, Elena
Keywords: Sars-cov-2 Prediction Obesity Metabolic syndrome Cytokines Cytokine storm Covid-19 sars-cov-2 prediction obesity mortality metabolic syndrome cytokines
Abstract: The cytokine signature present in COVID-19 could provide information on the pathogenic mechanisms of the disease and could identify possible prognostic biomarkers and possible therapeutic targets. In this longitudinal work, we studied the clinical and biochemical parameters and circulating cytokine levels of 146 patients at the time of admission for COVID-19 and 4–6 weeks later. The main objective of this study was to determine whether basal cytokines could be early prognostic biomarkers of COVID-19, and also to analyze the impact of comorbidities, such as obesity or metabolic syndrome (MS), in the cytokine profile. The levels of most inflammatory cytokines were elevated on admission in relation to the level that was reached 4–6 weeks later, except for IL-1?, which was lower on admission; these levels were irrespective of the presence of obesity or MS since the cytokine storm masks these inflammatory processes. Among the cytokines analyzed, those that correlated with a worse prognosis of COVID-19 were resistin, IL-6, IL-8, IL-15, MCP-1 and TNF-?. Specifically, resistin and IL-15 are the best early predictors of requiring invasive ventilation. Therefore, resistin and IL-15 should be included in the personalized treatment decision algorithm of patients with COVID-19.
Thematic Areas: Science and technology studies Medicine, general & internal Medicine (miscellaneous) Health care sciences & services
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat jessicaangela.binetti@estudiants.urv.cat elena.yeregui@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat ximena.terra@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat jesusmiguel.lopez@urv.cat
Author identifier: 0000-0002-8039-2889 0000-0001-7808-5479 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0003-1043-5844 0000-0002-4440-562X 0000-0002-4440-562X https://orcid.org/0000-0003-0396-6428 0000-0003-0396-6428 0000-0002-9141-2523
Record's date: 2024-12-21
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: J Pers Med. 12 (3): 391-
APA: Perpinan, Carles; Bertran, Laia; Terra, Ximena; Aguilar, Carmen; Binetti, Jessica; Lopez-Dupla, Miguel; Rull, Anna; Reverte, Laia; Yeregui, Elena; Gom (2022). Resistin and IL-15 as Predictors of Invasive Mechanical Ventilation in COVID-19 Pneumonia Irrespective of the Presence of Obesity and Metabolic Syndrome. J Pers Med, 12(3), 391-. DOI: 10.3390/jpm12030391
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV