Articles producció científica> Medicina i Cirurgia

A systematic review on genome-wide association studies exploring comorbidity in bipolar disorder

  • Identification data

    Identifier: imarina:9247323
  • Authors:

    Aranda S
    Jiménez E
    Martorell L
    Muntané G
    Vieta E
    Vilella E
  • Others:

    Author, as appears in the article.: Aranda S; Jiménez E; Martorell L; Muntané G; Vieta E; Vilella E
    Department: Medicina i Cirurgia
    URV's Author/s: Aranda Castel, Selena / Martorell Bonet, Lourdes / Muntané Medina, Gerard / Vilella Cuadrada, Elisabet
    Keywords: Single nucleotide polymorphism Genome-wide association study Endophenotype Comorbidity Bipolar disorder
    Abstract: Background: The comorbidities associated with bipolar disorder (BD) can worsen patients’ prognosis and increase economic costs to society. Currently, efforts are being made to identify new endophenotypes characterized by the presence of BD and another concomitant condition. Methods: We performed a search on PubMed and GWAS catalog databases to find genome-wide association studies carried out on patients with BD with any other comorbid condition. We extracted the associated SNPs that attained statistical significance and listed them to appraise their potential to define new BD endophenotypes based on the presence of comorbidities. Results: Six articles fulfilled the inclusion criteria, and all included only patients with BD type-I (BDI). The identified comorbid conditions were migraine, externalizing disorders and eating disorders. BDI with comorbid migraine was associated with rs1160720 in the NBEA gene. BDI with comorbid anorexia or bulimia nervosa was associated with rs4854912 and rs13100379 in the SOX2-OT gene. BDI with comorbid substance abuse was associated with rs1039002 in the PDE10A gene, rs12563333 upstream of the MARK1 gene, and rs13220542 downstream of the MAP3K7 gene. BDI with comorbid alcohol dependence and substance abuse was associated with rs2727943, which is located between CNTN4 and CNTN6. However, such associations were not strong enough to replicate. Limitations: The main limitations are the small size and poor description of the samples used in the included articles. Conclusions: Some genes involved in neurotransmission, stress response, neurogenesis and synaptic plasticity may be associated with comorbid BDI. However, evidence is too weak to consider new endophenotypes in BDI.
    Thematic Areas: Psychiatry and mental health Clinical psychology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: gerard.muntane@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat selena.aranda@estudiants.urv.cat
    Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919
    Record's date: 2024-06-15
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S2666915321000573?via%3Dihub#!
    Papper original source: Journal Of Affective Disorders Reports. 4
    APA: Aranda S; Jiménez E; Martorell L; Muntané G; Vieta E; Vilella E (2021). A systematic review on genome-wide association studies exploring comorbidity in bipolar disorder. Journal Of Affective Disorders Reports, 4(), -. DOI: 10.1016/j.jadr.2021.100130
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.jadr.2021.100130
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Clinical Psychology,Psychiatry and Mental Health
    Single nucleotide polymorphism
    Genome-wide association study
    Endophenotype
    Comorbidity
    Bipolar disorder
    Psychiatry and mental health
    Clinical psychology
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