Author, as appears in the article.: Macià A; Romero MP; Yuste S; Ludwig I; Pedret A; Valls RM; Salamanca P; Solà R; José Motilva M; Rubió L
Department: Medicina i Cirurgia
URV's Author/s: Pedret Figuerola, Anna / Salamanca González, Patricia / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
Keywords: Uplc-ms/ms Red-fleshed apple Metabolism Intake biomarkers Anthocyanins uplc-ms/ms red-fleshed apple polyphenols plasma microbiota metabolism juice intake biomarkers health excretion bioavailability acid
Abstract: The present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-week) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2′-O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human health.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, applied Biotecnología Biodiversidade Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: anna.pedret@urv.cat patricia.salamanca@estudiants.urv.cat patricia.salamanca@estudiants.urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat
Author identifier: 0000-0002-5327-932X 0000-0002-3351-0942 0000-0002-8359-235X
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S030881462200574X
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Food Chemistry. 384 132612-
APA: Macià A; Romero MP; Yuste S; Ludwig I; Pedret A; Valls RM; Salamanca P; Solà R; José Motilva M; Rubió L (2022). Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study. Food Chemistry, 384(), 132612-. DOI: 10.1016/j.foodchem.2022.132612
Article's DOI: 10.1016/j.foodchem.2022.132612
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV