Author, as appears in the article.: Paz-Graniel, I; Kose, J; Babio, N; Hercberg, S; Galan, P; Touvier, M; Salas-Salvadó, J; Andreeva, VA
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge
Keywords: Stai-t Middle aged Mental health Male Logistic models Humans Gender-differences Female Epidemiological study Dietary intake Cross-sectional studies Caffeine Anxiety disorders Anxiety Aged Adult stress stai-t risk questionnaire mood metaanalysis mental health follow-up epidemiological study dietary intake depression consumption coffee anxiety
Abstract: (1) Background: Caffeine is one of the most consumed psychoactive stimulants worldwide. It has been suggested that caffeine intake at large doses can induce anxiety, whereas evidence of the role of low to moderate caffeine intake is scarce and inconsistent. Therefore, we aimed to assess the association between caffeine intake and general anxiety in adults recruited from the general population. (2) Methods: Participants from the French NutriNet-Santé web cohort with data on caffeine intake and general anxiety (assessed during 2013–2016 through the trait subscale of Spielberger’s State-Trait Anxiety Inventory Form Y; STAI-T, sex-specific top quartile = high trait anxiety) were included in this cross-sectional analysis (n = 24,197; 74.1% women; mean age = 53.7 ± 13.9 years). Mean dietary intake was estimated using ≥2 self-reported 24-h dietary records. Sex-specific tertiles of caffeine intake and low/high trait anxiety were calculated. Multivariable logistic regression models were fitted to assess the odds ratio (OR) and 95% confidence interval (CI) for the association between caffeine intake and general anxiety by sex. (3) Results: In the total sample, the mean caffeine intake (mg/day) from all dietary sources combined was 220.6 ± 165.0 (women = 212.4 ± 159.6; men = 243.8 ± 177.7, p < 0.01). Women in the highest tertile of caffeine intake showed significantly higher odds for high trait anxiety compared to those in the lowest tertile (reference), even after adjustment for potential confounders (OR: 1.13; 95% CI: 1.03–1.23). No significant associations were detected among men. Sensitivity analyses according to perceived stress level and sugar intake, respectively, showed similar results. (4) Conclusions: The results suggest that higher caffeine intake is associated with higher odds of general anxiety among women but not among men. Further research is needed to confirm the sex-specific findings and elucidate the potential causal relationship between caffeine intake and anxiety status.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: indiradelsocorro.paz@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-3204-6877 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/6/1242
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (6): 1242-
APA: Paz-Graniel, I; Kose, J; Babio, N; Hercberg, S; Galan, P; Touvier, M; Salas-Salvadó, J; Andreeva, VA (2022). Caffeine Intake and Its Sex-Specific Association with General Anxiety: A Cross-Sectional Analysis among General Population Adults. Nutrients, 14(6), 1242-. DOI: 10.3390/nu14061242
Article's DOI: 10.3390/nu14061242
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV