Articles producció científica> Medicina i Cirurgia

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

  • Identification data

    Identifier: imarina:9249031
    Handle: http://hdl.handle.net/20.500.11797/imarina9249031
  • Authors:

    Solomon O
    Huen K
    Yousefi P
    Küpers LK
    González JR
    Suderman M
    Reese SE
    Page CM
    Gruzieva O
    Rzehak P
    Gao L
    Bakulski KM
    Novoloaca A
    Allard C
    Pappa I
    Llambrich M
    Vives M
    Jima DD
    Kvist T
    Baccarelli A
    White C
    Rezwan FI
    Sharp GC
    Tindula G
    Bergström A
    Grote V
    Dou JF
    Isaevska E
    Magnus MC
    Corpeleijn E
    Perron P
    Jaddoe VWV
    Nohr EA
    Maitre L
    Foraster M
    Hoyo C
    Håberg SE
    Lahti J
    DeMeo DL
    Zhang H
    Karmaus W
    Kull I
    Koletzko B
    Feinberg JI
    Gagliardi L
    Bouchard L
    Ramlau-Hansen CH
    Tiemeier H
    Santorelli G
    Maguire RL
    Czamara D
    Litonjua AA
    Langhendries JP
    Plusquin M
    Lepeule J
    Binder EB
    Verduci E
    Dwyer T
    Carracedo Á
    Ferre N
    Eskenazi B
    Kogevinas M
    Nawrot TS
    Munthe-Kaas MC
    Herceg Z
    Relton C
    Melén E
    Gruszfeld D
    Breton C
    Fallin MD
    Ghantous A
    Nystad W
    Heude B
    Snieder H
    Hivert MF
    Felix JF
    Sørensen TIA
    Bustamante M
    Murphy SK
    Raikkönen K
    Oken E
    Holloway JW
    Arshad SH
    London SJ
    Holland N
  • Others:

    Author, as appears in the article.: Solomon O; Huen K; Yousefi P; Küpers LK; González JR; Suderman M; Reese SE; Page CM; Gruzieva O; Rzehak P; Gao L; Bakulski KM; Novoloaca A; Allard C; Pappa I; Llambrich M; Vives M; Jima DD; Kvist T; Baccarelli A; White C; Rezwan FI; Sharp GC; Tindula G; Bergström A; Grote V; Dou JF; Isaevska E; Magnus MC; Corpeleijn E; Perron P; Jaddoe VWV; Nohr EA; Maitre L; Foraster M; Hoyo C; Håberg SE; Lahti J; DeMeo DL; Zhang H; Karmaus W; Kull I; Koletzko B; Feinberg JI; Gagliardi L; Bouchard L; Ramlau-Hansen CH; Tiemeier H; Santorelli G; Maguire RL; Czamara D; Litonjua AA; Langhendries JP; Plusquin M; Lepeule J; Binder EB; Verduci E; Dwyer T; Carracedo Á; Ferre N; Eskenazi B; Kogevinas M; Nawrot TS; Munthe-Kaas MC; Herceg Z; Relton C; Melén E; Gruszfeld D; Breton C; Fallin MD; Ghantous A; Nystad W; Heude B; Snieder H; Hivert MF; Felix JF; Sørensen TIA; Bustamante M; Murphy SK; Raikkönen K; Oken E; Holloway JW; Arshad SH; London SJ; Holland N
    Department: Medicina i Cirurgia
    URV's Author/s: Ferre Pallas, Natalia
    Keywords: Sex Gene Ewas Dna methylation Cord blood Children sex pregnancy package information gender expression ewas cord blood children
    Abstract: Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits. Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268). Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction. Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes.
    Thematic Areas: Toxicology Medicina ii Medicina i Health, toxicology and mutagenesis Genetics & heredity Genetics General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biotechnology & applied microbiology Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: natalia.ferre@urv.cat
    Author identifier: 0000-0002-2838-1525
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1383574222000059
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Mutation Research-Reviews In Mutation Research. 789
    APA: Solomon O; Huen K; Yousefi P; Küpers LK; González JR; Suderman M; Reese SE; Page CM; Gruzieva O; Rzehak P; Gao L; Bakulski KM; Novoloaca A; Allard C; (2022). Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. Mutation Research-Reviews In Mutation Research, 789(), -. DOI: 10.1016/j.mrrev.2022.108415
    Article's DOI: 10.1016/j.mrrev.2022.108415
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biotechnology & Applied Microbiology,Genetics,Genetics & Heredity,Health, Toxicology and Mutagenesis,Toxicology
    Sex
    Gene
    Ewas
    Dna methylation
    Cord blood
    Children
    sex
    pregnancy
    package
    information
    gender
    expression
    ewas
    cord blood
    children
    Toxicology
    Medicina ii
    Medicina i
    Health, toxicology and mutagenesis
    Genetics & heredity
    Genetics
    General medicine
    Farmacia
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biotechnology & applied microbiology
    Biodiversidade
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