Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Identifier:  imarina:9249431

Handle: https://hdl.handle.net/20.500.11797/imarina9249431

Authors:  Valle-Hita, Cristina; Diaz-Lopez, Andres; Becerra-Tomas, Nerea; Martinez-Gonzalez, Miguel A; Garcia, Veronica Ruiz; Corella, Dolores; Goday, Albert; Martinez, J Alfredo; Alonso-Gomez, Angel M; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Serra-Majem, Luis; Cano-Ibanez, Naomi; Tur, Josep A; Rubin-Garcia, Maria; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Fontao, Sebastian Mas; Daimiel, Lidia; Ros, Emilio; Toledo, Estefania; Sorli, Jose, V; Roca, C; Abete, Iztiar; Moreno-Rodriguez, Anai; Crespo-Oliva, Edelys; Candela-Garcia, Inmaculada; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Diez-Espino, Javier; Ortega-Azorin, Carolina; Comas, M; Zulet, M Angeles; Sorto-Sanchez, Carolina; Ruiz-Canela, Miguel; Fito, Montse; Salas-Salvado, Jordi; Babio, Nancy

Abstract:
To assess the association between three different a priori dietary patterns adherence (17-item energy reduced-Mediterranean Diet (MedDiet), Trichopoulou-MedDiet and Dietary Approach to Stop Hypertension (DASH)), as well as the Protein Diet Score and kidney function decline after one year of follow-up in elderly individuals with overweight/obesity and metabolic syndrome (MetS).We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate.Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75).Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health.ISRCTN89898870 (Data of registration: 2014).© 2022. The Author(s).