Articles producció científicaQuímica Analítica i Química Orgànica

Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters

  • Identification data

    Identifier:  imarina:9258940
    Handle: https://hdl.handle.net/20.500.11797/imarina9258940
    Authors:  Jiang L; Sarró P; Teo WJ; Llop J; Suero MG
    Abstract:
    Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp(2))-C(sp(2)) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.

  • Others:

    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2022/sc/d2sc00968d
    APA: Jiang L; Sarró P; Teo WJ; Llop J; Suero MG (2022). Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters. Chemical Science, (), -. DOI: 10.1039/d2sc00968d
    Paper original source: Chemical Science.
    Article's DOI: 10.1039/d2sc00968d
    Journal publication year: 2022
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2024-09-07
    URV's Author/s: Sarró Grané, Pau
    Department: Química Analítica i Química Orgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Jiang L; Sarró P; Teo WJ; Llop J; Suero MG
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Química, Materiais, Interdisciplinar, General chemistry, Farmacia, Ciências biológicas iii, Ciências biológicas i, Chemistry, multidisciplinary, Chemistry (miscellaneous), Chemistry (all), Astronomia / física
    Author's mail: pau.sarro@estudiants.urv.cat

  • Keywords:

    Phase-transfer catalysis
    Nonsteroidal antiinflammatory drugs
    Enantioselective fluorination
    Decarboxylative fluorination
    Combination
    Chemistry
    Asymmetric fluorination
    Alkyl fluorides
    Activation
    Acids
    Chemistry (Miscellaneous)
    Multidisciplinary
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Ciências biológicas iii
    Ciências biológicas i
    Chemistry (all)
    Astronomia / física

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