Author, as appears in the article.: Jiang L; Sarró P; Teo WJ; Llop J; Suero MG
Department: Química Analítica i Química Orgànica
URV's Author/s: Sarró Grané, Pau
Keywords: Phase-transfer catalysis Nonsteroidal antiinflammatory drugs Enantioselective fluorination Decarboxylative fluorination Combination Chemistry Asymmetric fluorination Alkyl fluorides Activation Acids
Abstract: Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp(2))-C(sp(2)) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.
Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Ciências biológicas iii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: pau.sarro@estudiants.urv.cat
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2022/sc/d2sc00968d
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Chemical Science.
APA: Jiang L; Sarró P; Teo WJ; Llop J; Suero MG (2022). Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters. Chemical Science, (), -. DOI: 10.1039/d2sc00968d
Article's DOI: 10.1039/d2sc00968d
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV