Articles producció científicaQuímica Analítica i Química Orgànica

Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters

  • Identification data

    Identifier:  imarina:9258940
    Handle: https://hdl.handle.net/20.500.11797/imarina9258940
    Authors:  Jiang, LY; Sarró, P; Teo, WJ; Llop, J; Suero, MG
    Abstract:
    Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp(2))-C(sp(2)) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.

  • Others:

    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2022/sc/d2sc00968d
    APA: Jiang, LY; Sarró, P; Teo, WJ; Llop, J; Suero, MG (2022). Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters. Chemical Science, 13(15), 4327-4333. DOI: 10.1039/d2sc00968d
    Paper original source: Chemical Science. 13 (15): 4327-4333
    Article's DOI: 10.1039/d2sc00968d
    Journal publication year: 2022-04-13
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-05-09
    URV's Author/s: Sarró Grané, Pau
    Department: Química Analítica i Química Orgànica
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    Author, as appears in the article.: Jiang, LY; Sarró, P; Teo, WJ; Llop, J; Suero, MG
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: General chemistry, Farmacia, Chemistry, multidisciplinary, Chemistry (miscellaneous), Chemistry (all), Astronomia / física
    Author's mail: pau.sarro@estudiants.urv.cat

  • Keywords:

    Phase-transfer catalysis
    Nonsteroidal antiinflammatory drugs
    Enantioselective fluorination
    Decarboxylative fluorination
    Combination
    Chemistry
    Asymmetric fluorination
    Alkyl fluorides
    Activation
    Acids
    Chemistry (Miscellaneous)
    Multidisciplinary
    General chemistry
    Farmacia
    Chemistry (all)
    Astronomia / física

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